Temporal Trends in Takotsubo Syndrome Results From the International Takotsubo Registry

被引：3

作者：

Schweiger, Victor ^{[1
,2
,3
]}

Cammann, Victoria L. ^{[1
,2
]}

Crisci, Giulia ^{[4
]}

Gilhofer, Thomas ^{[1
,2
]}

Schlenker, Rabea ^{[1
,2
]}

Niederseer, David ^{[5
,6
,7
]}

Chen, Shaojie ^{[8
]}

Ebrahimi, Ramin ^{[8
,9
]}

Wenzl, Florian ^{[10
]}

Wurdinger, Michael ^{[1
,2
]}

Citro, Rodolfo ^{[11
,12
]}

Vecchione, Carmine ^{[11
,13
]}

Gili, Sebastiano ^{[14
]}

Neuhaus, Michael ^{[15
]}

Franke, Jennifer ^{[16
]}

Meder, Benjamin ^{[16
]}

Jaguszewski, Milosz ^{[17
]}

Noutsias, Michel ^{[18
]}

Knorr, Maike ^{[19
]}

Jansen, Thomas ^{[19
]}

D'Ascenzo, Fabrizio ^{[20
]}

Dichtl, Wolfgang ^{[21
]}

von Lewinski, Dirk ^{[22
]}

Burgdorf, Christof ^{[23
]}

Kherad, Behrouz ^{[3
]}

Tschoepe, Carsten ^{[3
]}

Sarcon, Annahita ^{[24
]}

Shinbane, Jerold ^{[25
]}

Rajan, Lawrence ^{[26
]}

Michels, Guido ^{[27
]}

Pfister, Roman ^{[3
]}

Cuneo, Alessandro ^{[28
]}

Jacobshagen, Claudius ^{[29
,30
]}

Karakas, Mahir ^{[31
,32
]}

Koenig, Wolfgang ^{[33
,34
]}

Pott, Alexander ^{[35
]}

Meyer, Philippe ^{[36
]}

Roffi, Marco ^{[36
]}

Banning, Adrian ^{[37
]}

Wolfrum, Mathias ^{[38
]}

Cuculi, Florim ^{[38
]}

Kobza, Richard ^{[38
]}

Fischer, Thomas A. ^{[39
]}

Vasankari, Tuija ^{[40
,41
]}

Airaksinen, K. E. Juhani ^{[40
,41
]}

Napp, L. Christian ^{[42
]}

Dworakowski, Rafal ^{[43
]}

MacCarthy, Philip ^{[43
]}

Kaiser, Christoph ^{[44
]}

Osswald, Stefan ^{[44
]}

机构：

[1] Univ Hosp Zurich, Dept Cardiol, Univ Heart Ctr, Ramistr 100, CH-8091 Zurich, Switzerland

[2] Univ Zurich, Zurich, Switzerland

[3] Deutsch Herzzentrum Charite, Angiol & Intens Care Med, Dept Cardiol, Berlin, Germany

[4] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy

[5] Hochgebirgsklinik, Med Campus Davos, Davos, Switzerland

[6] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Med Campus Davos, Davos, Switzerland

[7] Univ Hosp Zurich, Ctr Translat & Expt Cardiol, Zurich, Switzerland

[8] Goethe Univ Frankfurt Main, Akad Lehrkrankenhaus, Cardioangiol Ctr Bethanien CCB, Agaples Markus Krankenhaus,Kardiol,Med Klin 3, Frankfurt, Germany

[9] Zentrum Kardiol, Heart Clin Pratteln, Pratteln, Switzerland

[10] Univ Zurich, Ctr Mol Cardiol, Schlieren Campus, Zurich, Switzerland

[11] IRCCS Neuromed, Dept Vasc Physiopathol, Pozzilli, Italy

[12] Univ Molise, Dept Med & Hlth Sci, Div Clin Cardiol Res Responsible Hosp, Campobasso, Italy

[13] Univ Salerno, Dept Med Surg & Dent, Salerno, Italy

[14] IRCCS, Ctr Cardiol Monzino, Milan, Italy

[15] Kantonsspital Frauenfeld, Dept Cardiol, Frauenfeld, Switzerland

[16] Heidelberg Univ Hosp, Dept Cardiol, Heidelberg, Germany

[17] Med Univ Gdansk, Dept Cardiol 1, Gdansk, Poland

[18] Martin Luther Univ Halle Wittenberg, Univ Hosp Halle, Div Cardiol Angiol & Intens Med Care, MidGerman Heart Ctr,Dept Internal Med 3, Halle, Saale, Germany

[19] Univ Med Ctr Mainz, Ctr Cardiol, Cardiol 1, Mainz, Germany

[20] Univ Turin, AOU Citta Salute & Sci, Dept Med Sci, Div Cardiol, Turin, Italy

[21] Med Univ Innsbruck, Univ Hosp Internal Med Cardiol & Angiol 3, Innsbruck, Austria

[22] Med Univ Graz, Div Cardiol, Graz, Austria

[23] Heart & Vasc Ctr Bad Bevensen, Bad Bevensen, Germany

[24] Univ Calif San Francisco, Dept Med, Sect Cardiac Electrophysiol, San Francisco, CA 94143 USA

[25] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USA

[26] TJ Hlth Partners Heart & Vasc, Glasgow, KY USA

[27] St Antonius Hosp gGmbH, Akad Lehrkrankenhaus RWTH Aachen, Klin Akut & Notfallmed, Eschweiler, Germany

[28] Krankenhaus Maria Hilf Med Klin, Stadtlohn, Germany

[29] Georg August Univ Goettingen, Clin Cardiol & Pneumol, Gottingen, Germany

[30] Vincentius Diakonissen Hosp, Karlsruhe, Germany

[31] Univ Med Ctr Hamburg Eppendorf, Dept Intens Care Med, Hamburg, Germany

[32] DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Kiel Luebeck, Hamburg, Germany

[33] Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany

[34] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

[35] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany

[36] Hop Univ Geneve, Serv Cardiol, Geneva, Switzerland

[37] Oxford Univ Hosp, John Radcliffe Hosp, Dept Cardiol, Oxford, England

[38] Kantonsspital Lucerne, Dept Cardiol, Luzern, Switzerland

[39] Kantonsspital Winterthur, Dept Cardiol, Winterthur, Switzerland

[40] Turku Univ Hosp, Heart Ctr, Turku, Finland

[41] Univ Turku, Turku, Finland

[42] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany

[43] Kings Coll Hosp London, Dept Cardiol, London, England

[44] Univ Hosp Basel, Dept Cardiol, Basel, Switzerland

[45] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[46] Christchurch Hosp, Dept Cardiol, Christchurch, New Zealand

[47] Univ Med Greifswald, Dept Cardiol & Internal Med B, Greifswald, Germany

[48] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany

[49] Univ Hosp Rangueil, Dept Cardiol, Toulouse, France

[50] Univ Hosp Rangueil, Cardiac Imaging Ctr, Toulouse, France

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2024年 / 84卷 / 13期

关键词：

broken heart syndrome; stress cardiomyopathy; takotsubo syndrome; trends; MYOCARDIAL-INFARCTION; CLINICAL PROFILE; TAKO-TSUBO; OUTCOMES;

D O I：

10.1016/j.jacc.2024.05.076

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND The perception of takotsubo syndrome (TTS) has evolved significantly over the years, primarily driven by increased recognition of acute complications and mortality. OBJECTIVES This study aimed to explore temporal trends in demographic patterns, risk factors, clinical presentations, and outcomes in patients with TTS. METHODS Patients diagnosed with TTS between 2004 and 2021 were enrolled from the InterTAK (International Takotsubo) registry. To assess temporal trends, patients were divided into 6 groups, each corresponding to a 3-year interval within the study period. RESULTS Overall, 3,957 patients were included in the study. There was a significant demographic transition, with the proportion of male patients rising from 10% to 15% (P = 0.003). Although apical TTS remained the most common form, the diagnosis of midventricular TTS increased from 18% to 28% (P = 0.018). The prevalence of physical triggers increased from 39% to 58% over the years (P < 0.001). There was a significant increase in 60-day mortality over the years (P < 0.001). However, a landmark analysis excluding patients who died within the first 60 days showed no differences in 1-year mortality (P = 0.150). CONCLUSIONS This study of temporal trends in TTS highlights a transition in patients demographic with a growing prevalence among men, increasing recognition of midventricular TTS type, and increased short-term mortality and rates of cardiogenic shock in recent years. This transition aligns with the rising prevalence of physical triggers, as expression of increased recognition of TTS in association with acute comorbidities. (c) 2024 by the American College of Cardiology Foundation.

引用

页码：1178 / 1189

页数：12

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