Taxonomic and functional profiling of skin microbiome in psoriasis

被引：0

作者：

Sinkko, Hanna ^{[1
,2
]}

Olah, Peter ^{[3
,4
]}

Yang, Ying ^{[1
]}

Maia, Guilherme

Barrientos-Somarribas, Mauricio ^{[5
]}

Radai, Zoltan ^{[3
,6
]}

Maenpaa, Kuunsaede ^{[2
]}

Soratto, Tatiany ^{[5
]}

Salava, Alexander ^{[7
,8
]}

Lauerma, Antti ^{[7
,8
]}

Barker, Jonathan ^{[9
]}

Ranki, Annamari ^{[7
,8
]}

Homey, Bernhard ^{[3
]}

Andersson, Bjoern ^{[5
]}

Fyhrquist, Nanna

Alenius, Harri ^{[1
,2
]}

MAARS Consortium, Juha

机构：

[1] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[2] Univ Helsinki, Med Fac, Human Microbiome Res Program HUMI, Helsinki, Finland

[3] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Med Fac, Dept Dermatol, Dusseldorf, Germany

[4] Univ Pecs, Med Fac, Dept Dermatol Venereol & Oncodermatol, Pecs, Hungary

[5] Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden

[6] Univ Debrecen, One Hlth Inst, Fac Hlth Sci, Debrecen, Hungary

[7] Univ Helsinki, Dept Dermatol Allergol & Venereol, Helsinki, Finland

[8] Helsinki Univ Hosp, Inflammat Ctr, Helsinki, Finland

[9] Kings Coll London, St Johns Inst Dermatol, London, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年

关键词：

D O I：

10.1093/bjd/ljae471

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This research utilizes whole metagenomic shotgun sequencing to analyse the skin microbiome in patients with psoriasis, comparing lesional and nonlesional skin with those of healthy individuals. The study identifies significant differences in the microbial composition and functionality between psoriatic and healthy skin, revealing distinct microbial patterns and disruptions in psoriatic skin. These findings highlight the complex role of skin microbiota in psoriasis, emphasizing variations in bacteria and their functional characteristics beyond mere species identification.

引用

页数：3

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