Synthesis of 2,4,5-vinylic-trisubstituted oxazoles via a Palladium-catalyzed cascade coupling reaction

被引：0
|
作者：
Ma, Jun [1 ,2 ]
Wang, Huali [1 ,2 ]
Meng, Qingyu [1 ]
Wang, Haoyue [1 ]
Li, Fangyi [1 ,2 ]
Li, Zheng [1 ,2 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin Key Lab Intelligent & Green Pharmaceut Tra, Tianjin 301617, Peoples R China
[2] State Key Lab Chinese Med Modernizat, Tianjin 301617, Peoples R China
来源：
TETRAHEDRON LETTERS | 2024年 / 153卷
关键词：
Trisubstituted oxazoles; Palladium-catalyzed; Ligand-free conditions; Cascade C-O/C-C bond formation; SUBSTITUTED OXAZOLES; ENAMIDES; DERIVATIVES; INDOLES;
D O I：
10.1016/j.tetlet.2024.155373
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel one-step synthesis of valuable 2,4,5-vinylic-trisubstituted oxazoles is described. This reaction, utilizing readily available (3,(3-dibrominated secondary enamides and terminal alkenes as starting materials, occurs via a ligand-free Palladium-catalyzed cascade intramolecular C-O coupling/intermolecular Heck reaction.
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页数：5
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