Exploiting the cGAS/STING pathway to revert the immunosuppressive environment of multiple myeloma and boost Natural Killer cell-mediated immunosurveillance

被引:0
|
作者
Cassone, Chiara [1 ]
Gnocchini, Eleonora [1 ]
Sproviero, Elena [1 ]
Fazio, Francesca [2 ]
Petrucci, Maria Teresa [2 ]
Cerboni, Cristina [1 ]
Soriani, Alessandra [1 ]
Cippitelli, Marco [1 ]
Zingoni, Alessandra [1 ]
机构
[1] Sapienza Univ Rome, Dept Mol Med, Rome, Italy
[2] Sapienza Univ Rome, Dept Cellular Biotechnol & Hematol, Rome, Italy
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
625 - P2.0
引用
收藏
页码:1076 / 1076
页数:1
相关论文
共 39 条
  • [21] Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma
    Shi, Jumei
    Tricot, Guido J.
    Garg, Tarun K.
    Malaviarachchi, Priyangi A.
    Szmania, Susann M.
    Kellum, Rachel E.
    Storrie, Brian
    Mulder, Arend
    Shaughnessy, John D., Jr.
    Barlogie, Bart
    van Rhee, Frits
    BLOOD, 2008, 111 (03) : 1309 - 1317
  • [22] VALPROIC ACID UPREGULATES NKG2D LIGAND EXPRESSION AND POTENTIALLY ENHANCES NATURAL KILLER CELL-MEDIATED CYTOLYSIS OF MYELOMA
    Shi, J.
    Tao, Y.
    Wu, X.
    Meng, X.
    Hu, X.
    Shao, Y.
    Hou, J.
    HAEMATOLOGICA, 2012, 97 : 595 - 595
  • [23] Cymbaria daurica L.: A Mongolian herbal medicine for treating eczema via natural killer cell-mediated cytotoxicity pathway
    Huang, Congying
    Li, Siqi
    Guo, Wenxin
    Zhang, Ziyan
    Meng, Xiangxi
    Li, Xing
    Gao, Bing
    Wen, Rong
    Niu, Hui
    Zhang, Chunhong
    Li, Minhui
    JOURNAL OF ETHNOPHARMACOLOGY, 2023, 308
  • [24] A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity
    Watkins-Schulz, Rebekah
    Tiet, Pamela
    Gallovic, Matthew D.
    Junkins, Robert D.
    Batty, Cole
    Bachelder, Eric M.
    Ainslie, Kristy M.
    Ting, Jenny P. Y.
    BIOMATERIALS, 2019, 205 : 94 - 105
  • [25] The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells
    El-Sherbiny, Yasser M.
    Meade, Josephine L.
    Holmes, Tim D.
    McGonagle, Dennis
    Mackie, Sarah L.
    Morgan, Ann W.
    Cook, Gordon
    Feyler, Sylvia
    Richards, Stephen J.
    Davies, Faith E.
    Morgan, Gareth J.
    Cook, Graham P.
    CANCER RESEARCH, 2007, 67 (18) : 8444 - 8449
  • [26] Sensitive Detection of the Natural Killer Cell-Mediated Cytotoxicity of Anti-CD20 Antibodies and Its Impairment by B-Cell Receptor Pathway Inhibitors
    Hassenrueck, Floyd
    Knoedgen, Eva
    Goeckeritz, Elisa
    Midda, Safi Hasan
    Vondey, Verena
    Neumann, Lars
    Herter, Sylvia
    Klein, Christian
    Hallek, Michael
    Krause, Guenter
    BIOMED RESEARCH INTERNATIONAL, 2018, 2018
  • [27] Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice
    Huang, Mei
    Sun, Rui
    Wei, Haiming
    Tian, Zhigang
    HEPATOLOGY, 2013, 57 (01) : 277 - 288
  • [28] HUMAN NATURAL-KILLER CELL-MEDIATED CYTOLYSIS OF K562 PROCEEDS VIA A PROTEIN-KINASE C-DEPENDENT PATHWAY
    STEELE, TA
    BRAHMI, Z
    FASEB JOURNAL, 1988, 2 (04): : A465 - A465
  • [29] Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway
    Zhu, Yiying
    Zhao, Zhangxun
    Xue, Minggao
    Wang, Dan
    Su, Guifeng
    Ju, Xiaoman
    Yang, Qihong
    Zhang, Shaohua
    Fan, Dongmei
    Zhu, Huifang
    Yu, Min
    Li, Yan
    Kong, Lingmei
    Zhou, Hongyu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 659 : 10 - 19
  • [30] Cholecystohepatic shunt pathway reduces secondary bile acid accumulation to enhance natural killer T cell-mediated anti-hepatocellular carcinoma immunity
    Liu, Shenglu
    Gou, Haoxian
    Wei, Hui
    Chen, Shengdeng
    Zhuo, Shijie
    Luo, Ming
    Qin, Shu
    Zhang, Mengyu
    Chen, Jiatong
    Huang, Zhiwei
    Xia, Xianming
    Yang, Xiaoli
    He, Kai
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2024, 39 (08) : 1684 - 1694