Research progress on the biosynthesis, metabolic engineering, and pharmacology of bioactive compounds from the Lonicera genus

被引:2
|
作者
Chen, Xiaojie [1 ,2 ]
Li, Weiqiang [2 ]
Lu, Xu [1 ]
Tran, Lam-Son Phan [3 ]
Alolga, Raphael N. [1 ]
Yin, Xiaojian [1 ,2 ]
机构
[1] China Pharmaceut Univ, Inst Pharmaceut Sci, Dept Pharmacognosy, State Key Lab Nat Med, Nanjing 210009, Peoples R China
[2] Chinese Acad Sci, Northeast Inst Geog & Agroecol, Key Lab Soybean Mol Design Breeding, State Key Lab Black Soils Conservat & Utilizat, Changchun 130102, Peoples R China
[3] Texas Tech Univ, Inst Genom Crop Abiot Stress Tolerance, Dept Plant & Soil Sci, Lubbock, TX 79409 USA
来源
MEDICINAL PLANT BIOLOGY | 2024年 / 3卷
基金
中国国家自然科学基金;
关键词
QUINATE HYDROXYCINNAMOYL TRANSFERASE; CHLOROGENIC ACID BIOSYNTHESIS; FLOS-LONICERAE; NICOTIANA-BENTHAMIANA; AROMATIC-COMPOUNDS; MASS-SPECTROMETRY; ENZYME-ACTIVITIES; OXIDATIVE STRESS; JAPONICA THUNB; OLEANOLIC ACID;
D O I
10.48130/mpb-0024-0008
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The Lonicera genus with medicinal and edible characteristics is a rich source of bioactive compounds that together account for numerous health benefits. Plants within this genus have been used traditionally in China to treat heat-related illnesses, viral respiratory infections, skin diseases, and inflammation for thousands of years. The main bioactive compounds include chlorogenic acids, flavonoids, iridoids, and triterpene saponins. Aside from the role of this genus as a valuable medicinal resource, constituent members have also been used in the food and cosmetic industries. Due to the huge demand for plants within the Lonicera genus, and the propensity for overexploitation of the wild resources of Lonicera, there is a need to meet this demand via alternative and efficient strategies such as metabolic engineering and green production. Here, we provide a comprehensive review of relevant scientific literature covering the structure, biosynthesis, metabolic engineering, pharmacology and phylogenetic analysis of the main bioactive constituents of the Lonicera genus. Finally, we proffer suggestions on the prospects of fully exploiting and utilizing plants of the Lonicera genus as useful medicinal plant resources.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] Research Progress on Sesquiterpenes from the Genus Ainsliaea
    Zhang, Hui
    Sun, Ru-Ru
    Liu, Ya-Feng
    Guo, Xin
    Li, Chong-Long
    Nan, Ze-Dong
    Jiang, Zhi-Bo
    MOLECULES, 2024, 29 (22):
  • [22] Identification of antiparasitic bioactive compounds from the Psorospermum genus (Hypericaceae).
    Ortiz, Sergio
    Lenta, Bruno
    Kaiser, Marcel
    Deharo, Eric
    Girard, Nicolas
    Vonthron, Catherine
    PLANTA MEDICA, 2023, 89 (14) : 1366 - 1366
  • [23] Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases
    Nie, Lirong
    Song, Hang
    He, Ai
    Yao, Shun
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (23) : 2605 - 2624
  • [24] ENGINEERING THE PHARMACOLOGY OF PROTEINS: FROM RESEARCH TO THE CLINIC AND BEYOND
    Cho, H.
    BIOPOLYMERS, 2009, 92 (04) : 300 - 300
  • [25] Natural rubber biosynthesis in plants, the rubber transferase complex, and metabolic engineering progress and prospects
    Cherian, Sam
    Ryu, Stephen Beungtae
    Cornish, Katrina
    PLANT BIOTECHNOLOGY JOURNAL, 2019, 17 (11) : 2041 - 2061
  • [26] Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders
    Silva, Luis R.
    Jacinto, Telma A.
    Coutinho, Paula
    FOODS, 2022, 11 (03)
  • [27] A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics
    Su, Fazhi
    Sun, Yanping
    Zhu, Wenbo
    Bai, Chenxi
    Zhang, Wensen
    Luo, Yumeng
    Yang, Bingyou
    Kuang, Haixue
    Wang, Qiuhong
    JOURNAL OF ETHNOPHARMACOLOGY, 2022, 285
  • [28] Metabolic Engineering of Methylotroph for Biosynthesis of Biodegradable Copolyesters from Methanol
    Orita, Izumi
    Fuxin, Toshiaki
    JOURNAL OF THE JAPAN PETROLEUM INSTITUTE, 2022, 65 (06) : 213 - 220
  • [29] Metabolic engineering of Escherichia coli for the biosynthesis of α-copaene from glucose
    Zhang, Suping
    Zhao, Xin
    He, Xiyuan
    Yang, Liu
    Wang, Yilin
    Liu, Feng
    Wang, Chao
    Hua, Qiang
    Wu, Yongchao
    Liu, Zhijie
    BIOCHEMICAL ENGINEERING JOURNAL, 2022, 186
  • [30] Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms
    Zhou, Rong
    Liu, Zhao Kun
    Zhang, Ye Ni
    Wong, Jack Ho
    Ng, Tzi Bun
    Liu, Fang
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2019, 20 (03) : 196 - 219