Copper-Based MOFs as Heterogeneous Catalyst in Aza-Diels-Alder Reaction for the Synthesis of 6H-chromeno[4,3-b]quinoline Derivatives

The present study focuses on the synthesis of copper-based benzene dicarboxylic acid (Cu BDC) metal-organic frameworks (MOF) and its application as a catalyst in the synthesis of 6H-chromeno[4,3-b] quinoline derivatives via Aza-Diels-Alder reactions. Aromatic amines and derivatives of O-propargylated salicylaldehyde are employed in this synthetic strategy. The synthesized Cu BDC MOFs were studied using powder X-ray Diffraction (PXRD), Fourier Transform Infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and energy-dispersive X-ray (EDX). The Cu BDC MOF's efficiency and reusability as catalysts have been demonstrated in the Aza-Diels-Alder reaction for the first time. Additionally, we proposed a mechanism for the Cu BDC MOF-mediated synthesis of chromenoquinolines, considering experimental results and literature reports.