Calcium catalysed Strecker-type reactions towards α-aminonitriles

被引：0
|
作者：
Basson, Ashley J. [1 ]
Cameron, Michael P. [2 ]
Mclaughlin, Mark G. [1 ,2 ]
机构：
[1] Univ Lancaster, Dept Chem, Bailrigg LA1 4YQ, England
[2] Queens Univ Belfast, Sch Chem & Chem Engn, Belfast, North Ireland
来源：
CHEMICAL COMMUNICATIONS | 2025年
基金：
英国工程与自然科学研究理事会;
关键词：
DIRECT CYANATION; HYDROLYSIS; NITRILES; ALCOHOLS;
D O I：
10.1039/d5cc00539f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of alpha-aminonitriles from readily available N,O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.
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页数：3
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