[1,2]-Phospha-Brook Rearrangement-Initiated Palladium-Catalyzed Cyclization Reaction of Isocyanides and o-Bromobenzaldehydes: Access to 2H-Isoindole-1-carboxamides and 2H-Isoindole-1-carbonitriles

被引：0
|
作者：
Wang, Binbin [1 ]
Gao, Qiushan [1 ]
Jiang, Huanfeng [1 ]
Wu, Wanqing [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2025年 / 43卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Palladium-catalyzed; Cyclization; 1,2]-Phospha-Brook rearrangement; Isocyanides; Insertion; Heterocycles; ISOINDOLES; DERIVATIVES; INSERTION; POTENT; BOND;
D O I：
10.1002/cjoc.202401015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, a [1,2]-phospha-Brook rearrangement-initiated palladium-catalyzed cyclization reaction for base-controlled selective synthesis of 2H-isoindole-1-carboxamide and 2H-isoindole-1-carbonitrile derivatives has been described. This strategy features double isocyanide insertion, efficient bond combinations, simple operation and reaction conditions. Mechanistic studies show that the [1,2]-phospha-Brook rearrangement is the key step in this reaction. This protocol offers a novel and concise strategy for the synthesis of 2H-isoindole derivatives.
引用
收藏
页码：620 / 626
页数：7
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