Photocatalytic Oxidation of α-Substituted Amines to Lactams/Amides

被引：0
|
作者：
Kumar, Manish [1 ,2 ]
Kumar, Pawan [1 ,2 ]
Das, Utpal [1 ,2 ]
机构：
[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2025年 / 367卷 / 03期
关键词：
alpha-Aminonitriles; Photocatalytic; Decyanation; Dioxetanimine; Pyrrolidine; GAMMA-LACTAMS;
D O I：
10.1002/adsc.202400871
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We, herein, report a base free, photocatalytic decyanation of alpha-aminonitriles. A range of amides and lactams were obtained in 52-95% yields. Control experiments indicate O2 as an amide/lactam oxygen source and the reaction (lactam formation) follows radical pathway via dioxetanimine species. This methodology also applied for alpha-ester/aldehyde substituted pyrrolidines in the presence of a base, probably via decarboxylation pathway.
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页数：5
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