A Phase Ib/II Study of Trovocabtagene Autoleucel (C-CAR088), an Anti-BCMA CAR T-Cell Therapy in Relapsed or Refractory Multiple Myeloma

被引：0
|
作者：
An, Gang [1 ]
Xu, Yan [1 ]
Yi, Shuhua [1 ]
Lyu, Rui [1 ]
Huang, Jiaqi [2 ]
Li, Wensi [2 ]
Zhang, Yiran [2 ]
Lan, Liping [2 ]
Qiu, Lugui [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
[2] Shanghai AbelZeta Ltd, Shanghai, Peoples R China
来源：
BLOOD | 2024年 / 144卷
关键词：
D O I：
10.1182/blood-2024-194774
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：7235 / 7236
页数：2
相关论文
共 50 条
  • [41] Cardiovascular adverse events and outcomes after anti-BCMA CAR-T for relapsed and refractory multiple myeloma
    Stefanie Palfi
    Lauren C. Peres
    Himara Koelmeyer
    Melissa Alsina
    Rachid C. Baz
    Brandon J. Blue
    Salvatore Corallo
    Gabriel De Avila
    Ciara Freeman
    Rebecca Gonzalez
    Ariel Grajales-Cruz
    Kristy Harvey
    Hien D. Liu
    Taiga Nishihori
    Guilherme H. Oliveira
    Laura B. Oswald
    Omar Castaneda Puglianini
    Sruthi Selvakumar
    Alexis Behne Sharma
    Elicia Wang
    Kenneth H. Shain
    Michael Jain
    Frederick L. Locke
    Mohammed Alomar
    Doris K. Hansen
    Dae Hyun Lee
    Blood Cancer Journal, 15 (1)
  • [42] First-in-human multicenter study of bb2121 anti-BCMA CAR T-cell therapy for relapsed/refractory multiple myeloma: Updated results.
    Berdeja, Jesus G.
    Lin, Yi
    Raje, Noopur S.
    Siegel, David Samuel DiCapua
    Munshi, Nikhil C.
    Liedtke, Michaela
    Jagannath, Sundar
    Maus, Marcela Valderrama
    Turka, Ashley
    Lam, Lyh Ping
    Hege, Kristen
    Morgan, Richard
    Quigley, M. Travis
    Kochenderfer, James
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [43] Phase 1 Trial of the Safety and Efficacy of Fully Human Anti-Bcma CAR T Cells in Relapsed/Refractory Multiple Myeloma
    Jie, Jin
    Hao, Siguo
    Jiang, Songfu
    Li, Zonghai
    Yang, Min
    Zhang, Wenhao
    Yu, Kang
    Xiao, Jun
    Meng, Haitao
    Ma, Liyuan
    He, Mingxia
    Wang, Wei
    Huang, Xin
    Chen, Linjun
    Xing, Chongyun
    Yuan, Daijing
    Wang, Shasha
    Tao, Rong
    Dai, Lihui
    Ma, Hong
    BLOOD, 2019, 134
  • [44] A combination of humanized anti-BCMA and murine anti-CD38 CAR-T cell therapy in patients with relapsed or refractory multiple myeloma
    Zhang, Huan
    Liu, Man
    Xiao, Xia
    Lv, Hairong
    Jiang, Yanyu
    Li, Xin
    Yuan, Ting
    Zhao, Mingfeng
    LEUKEMIA & LYMPHOMA, 2022, 63 (06) : 1418 - 1427
  • [45] SWASTH: Phase 1/2 Study of Ribrecabtagene Autoleucel, a BCMA-Directed CAR-T Cell Therapy, in Relapsed-Refractory Multiple Myeloma
    Menon, Hari
    Bharagava, Rahul
    Lokireddy, Padmaja
    Narayanan, Prasad
    Nataraj, K. S.
    Kumar, Akhil
    Mandavia, Divyesh
    Ramachandra, Murali
    Mathews, Vikram
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S65 - S65
  • [46] Risk Factors Associated with Durable Progression-Free Survival in Patients with Relapsed or Refractory Multiple Myeloma Treated with Anti-BCMA CAR T-cell Therapy
    Zhang, Mingming
    Zhou, Linghui
    Zhao, Houli
    Zhang, Yanlei
    Wei, Guoqing
    Hong, Ruimin
    Wu, Wenjun
    Xu, Huijun
    Wang, Linqin
    Ni, Fang
    Cui, Jiazhen
    Peng, Shuixiu
    Huang, Chih-Hua
    Chang, Alex H.
    Hu, Yongxian
    Huang, He
    CLINICAL CANCER RESEARCH, 2021, 27 (23) : 6384 - 6392
  • [47] High Efficacy and Safety of Nanobody Based Anti-BCMA CAR-T Cell Therapy in Treating Patients with Relapsed or Refractory Multiple Myeloma
    Zhang, Xian
    Wang, Lin
    Yang, Junfang
    Li, Jingjing
    Liu, Hongxing
    Li, Jianqiang
    Lu, Peihua
    BLOOD, 2023, 142
  • [48] Incidence of Parkinsonism As a Complication of Anti-BCMA CAR-T Cell Therapy in Multiple Myeloma
    Singh, Vaishnavi
    Master, Samip
    BLOOD, 2023, 142
  • [49] Phase II Study of Fully Human BCMA-Targeting CAR-T Cells (Zevorcabtagene Autoleucel) in Patients with Relapsed/ Refractory Multiple Myeloma
    Chen, Wenming
    Fu, Chengcheng
    Fang, Baijun
    Liang, Aibin
    Xia, Zhongjun
    He, Yanjuan
    Lu, Jin
    Liu, Hui
    Hou, Ming
    Cai, Zhen
    Yang, Wei
    Hao, Siguo
    Jiang, Songfu
    Jing, Hongmei
    Liu, Jing
    Du, Xin
    Fu, Rong
    Mei, Heng
    Zhu, Zunmin
    Yang, Yanli
    Liu, Hong
    Yuan, Daijing
    Zhao, Hongxia
    Xiao, Jun
    Wang, Wei
    Wang, Huamao
    Li, Zonghai
    BLOOD, 2022, 140 : 4564 - 4565
  • [50] JCARH125, Anti-BCMA CAR T-cell Therapy for Relapsed/Refractory Multiple Myeloma: Initial Proof of Concept Results from a Phase 1/2 Multicenter Study (EVOLVE)
    Mailankody, Sham
    Htut, Myo
    Lee, Kelvin P.
    Bensinger, William
    Devries, Todd
    Piasecki, Julia
    Ziyad, Safiyyah
    Blake, Michelle
    Byon, John
    Jakubowiak, Andrzej
    BLOOD, 2018, 132
12345