Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis

被引:0
|
作者
Li, Hai-Shuang [1 ]
Liu, Hui-Jie [1 ]
Zhang, Yu [1 ]
Zhang, Jing [1 ]
Yan, Han-Yu [1 ]
Yuan, Wei-Cheng [1 ]
Wang, Sen [1 ]
Yu, Shuo [1 ]
Yang, Sheng-Qiang [1 ]
Sun, Meng-Wei [1 ]
Qi, Can-Yang [1 ]
Miao, Sui-Bing [3 ]
Zhang, Li-Ping [1 ]
Guo, Hui [4 ]
Zhang, Yi [1 ]
Ma, Hui-Jie [1 ,2 ,5 ]
Guan, Yue [1 ,2 ]
机构
[1] Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Peoples R China
[2] Hebei Key Lab Neurophysiol, Shijiazhuang 050017, Peoples R China
[3] Hebei Med Univ, Hosp Shijiazhuang 4, Key Lab Maternal & Fetal Med Hebei Prov, Shijiazhuang 050017, Peoples R China
[4] Hebei Med Univ, Hosp 4, Dept Gynaecol & Obstet, Shijiazhuang 050017, Peoples R China
[5] Minist Educ, Key Lab Neural & Vasc Biol, Shijiazhuang 050017, Peoples R China
基金
中国国家自然科学基金;
关键词
Chronic intermittent hypobaric hypoxia; Pulmonary artery hypertension; Nitric oxide synthase hyperactivation; Calmodulin; Caveolin-1; NITRIC-OXIDE SYNTHASE; CAVEOLIN-1; THERAPY; MODEL; CELL; NO;
D O I
10.1016/j.abb.2025.110340
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aims: Pulmonary arterial hypertension (PAH) is a pathological condition in which pulmonary artery pressure is elevated which causes patients to die of right heart failure. Chronic intermittent hypobaric hypoxia (CIHH) represents a novel method of intermittently exposing subjects to a simulated plateau hypobaric hypoxia environment. This study investigates the potential preventive and protective effects of CIHH on PAH. Main methods: Male Sprague-Dawley rats were randomly divided into four groups: control group (Con), chronic intermittent hypobaric hypoxia group (CIHH), pulmonary arterial hypertension group (PAH), chronic intermittent hypobaric hypoxia + pulmonary arterial hypertension group (CIHH + PAH). To evaluate the effects of CIHH on PAH, a range of techniques was employed, including pulmonary hemodynamics, vascular reactivity assay, Western blot, RNA sequencing, HE staining and co-immunoprecipitation. Key findings: CIHH was demonstrated to reduce pulmonary artery constriction and enhance relaxation, reducing the mean pulmonary artery pressure in PAH rats. This is achieved through attenuating the CaM/eNOS (Calmodulin,CaM)protein interaction and increasing the CaV1/eNOS (Caveolin-1,CaV1) protein interaction, thereby preventing eNOS overactivation contribution to improving NO bioavailability in PAH rats. Significance: CIHH prevents PAH by maintaining eNOS homeostasis in PAH rats.
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页数:12
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