Fusaricate L, a new fusaric acid derivative from mangrove rhizosphere soil-derived Streptomyces angustmyceticus J-71

An undescribed fusaric acid derivative, fusaricate L (1) was isolated together with eight known compounds (2-9) from mangrove plant Rhizophora apiculata rhizosphere soil-derived Streptomyces angustmyceticus J-71. The structures of these compounds were established by extensive NMR spectroscopic data and comparison with the data of literature. Moreover, all isolated metabolites were tested for antifungal and antibacterial activities against a panel of plant and human pathogens. Compounds 4, 6, 7 and 9 showed modest antimicrobial activities towards methicillin- susceptible Staphylococcus aureus.