Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors

被引：0

作者：

Liu, Runhan ^{[1
,2
,3
]}

Zhou, Jiaxin ^{[4
,5
]}

Chen, Xiaochen ^{[4
]}

Zhang, Jie ^{[4
,5
]}

Chen, Qunzhi ^{[4
]}

Liu, Xiaoming ^{[1
,2
]}

Yao, Kunhou ^{[1
,2
]}

机构：

[1] Henan Univ, Huaihe Hosp, Dept Gastrointestinal Surg, Kaifeng 475000, Peoples R China

[2] Henan Univ, Sch Clin Med, Kaifeng 475004, Peoples R China

[3] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW 2007, Australia

[4] Henan Univ, Sch Life Sci, Kaifeng 475004, Peoples R China

[5] Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China

来源：

BIOMEDICINES | 2025年 / 13卷 / 01期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

gastrointestinal tumors; RNA; diagnosis; drug resistance; precision medicine; LONG NONCODING RNA; PANCREATIC-CANCER CELLS; PROGNOSTIC BIOMARKER; POOR-PROGNOSIS; GASTRIC-CANCER; DELIVERY; PROLIFERATION; TUMORIGENESIS; RESISTANCE; CARCINOMA;

D O I：

10.3390/biomedicines13010047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative therapeutic agents. Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. Additionally, this review categorizes specific diagnostic biomarkers and RNA therapeutic targets based on tissue type, offering a comprehensive analysis of their role in advancing precision medicine for gastrointestinal tumors.

引用

页数：22

共 50 条

[41] Theranostics and Precision Medicine in Neuroendocrine Tumors
Velickovic, Filip
Vlajkovic, Marina
Stevic, Milos
Topic, Nina
Andelkovic, Tamara
Macut, Duro
ACTA FACULTATIS MEDICAE NAISSENSIS, 2023, 40 (03) : 259 - 269
[42] Acute myeloid leukemia in the era of precision medicine: recent advances in diagnostic classification and risk stratification
Kansal, Rina
CANCER BIOLOGY & MEDICINE, 2016, 13 (01) : 41 - 54
[43] Acute myeloid leukemia in the era of precision medicine:recent advances in diagnostic classification and risk stratification
Rina Kansal
Cancer Biology & Medicine, 2016, 13 (01) : 41 - 54
[44] Role of circular RNAs in gastrointestinal tumors and drug resistance
Shi-Jun Xi
Wen-Qi Cai
Qin-Qi Wang
Xiao-Chun Peng
World Journal of Clinical Cases, 2021, (34) : 10400 - 10417
[45] Role of circular RNAs in gastrointestinal tumors and drug resistance
Xi, Shi-Jun
Cai, Wen-Qi
Wang, Qin-Qi
Peng, Xiao-Chun
WORLD JOURNAL OF CLINICAL CASES, 2021, 9 (34) : 10400 - 10417
[46] Therapeutic innovation: Impact of precision medicine
Kolesar, Jill
Crismon, M. Lynn
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2018, 75 (02) : 27 - 30
[47] Gastrointestinal endocrine tumors: diagnostic strategy
Mathonnet, M.
JOURNAL DE CHIRURGIE, 2007, 144 (04): : 287 - 292
[48] Implementation of genomic medicine for gastrointestinal tumors
Furukawa, Yoichi
ANNALS OF GASTROENTEROLOGICAL SURGERY, 2018, 2 (04): : 246 - 252
[49] Paediatric gastrointestinal endoscopy in the Asian-Pacific region: Recent advances in diagnostic and therapeutic techniques
Huang, James Guoxian
Tanpowpong, Pornthep
WORLD JOURNAL OF GASTROENTEROLOGY, 2023, 29 (18) : 2717 - 2732
[50] Paediatric gastrointestinal endoscopy in the Asian-Pacific region:Recent advances in diagnostic and therapeutic techniques
James Guoxian Huang
Pornthep Tanpowpong
World Journal of Gastroenterology, 2023, (18) : 2717 - 2732

← 1 2 3 4 5 →