Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors

被引：0
|
作者：
Liu, Runhan [1 ,2 ,3 ]
Zhou, Jiaxin [4 ,5 ]
Chen, Xiaochen [4 ]
Zhang, Jie [4 ,5 ]
Chen, Qunzhi [4 ]
Liu, Xiaoming [1 ,2 ]
Yao, Kunhou [1 ,2 ]
机构：
[1] Henan Univ, Huaihe Hosp, Dept Gastrointestinal Surg, Kaifeng 475000, Peoples R China
[2] Henan Univ, Sch Clin Med, Kaifeng 475004, Peoples R China
[3] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW 2007, Australia
[4] Henan Univ, Sch Life Sci, Kaifeng 475004, Peoples R China
[5] Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China
来源：
BIOMEDICINES | 2025年 / 13卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
gastrointestinal tumors; RNA; diagnosis; drug resistance; precision medicine; LONG NONCODING RNA; PANCREATIC-CANCER CELLS; PROGNOSTIC BIOMARKER; POOR-PROGNOSIS; GASTRIC-CANCER; DELIVERY; PROLIFERATION; TUMORIGENESIS; RESISTANCE; CARCINOMA;
D O I：
10.3390/biomedicines13010047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative therapeutic agents. Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. Additionally, this review categorizes specific diagnostic biomarkers and RNA therapeutic targets based on tissue type, offering a comprehensive analysis of their role in advancing precision medicine for gastrointestinal tumors.
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页数：22
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