Macrophage pyroptosis and its crucial role in ALI/ARDS

被引：0
|
作者：
Cai, Yuju [1 ,2 ]
Shang, Luorui [1 ]
Zhou, Fangyuan [1 ]
Zhang, Mengqi [1 ]
Li, Jinxiao [1 ]
Wang, Shuhan [1 ]
Lin, Qifeng [1 ]
Huang, Jianghua [1 ]
Yang, Shenglan [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Clin Nutr, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷
基金：
中国国家自然科学基金;
关键词：
ALI (acute lung injury); ARDS (acute respiratory distress syndrome); pyroptosis; macrophage; -; cell; treatment; ACUTE RESPIRATORY-DISTRESS; ACUTE LUNG INJURY; NEUTROPHIL EXTRACELLULAR TRAPS; INNATE IMMUNE RECOGNITION; NF-KAPPA-B; INFLAMMASOME ACTIVATION; GASDERMIN D; ASC; MITOCHONDRIA; CASPASES;
D O I：
10.3389/fimmu.2025.1530849
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI/ARDS and provide novel insights for its treatment.
引用
收藏
页数：16
相关论文
共 50 条
  • [11] Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS
    Li, Haitao
    Li, Yi
    Song, Chao
    Hu, Yongbin
    Dai, Minhui
    Liu, Ben
    Pan, Pinhua
    JOURNAL OF INFLAMMATION RESEARCH, 2021, 14 : 4839 - 4858
  • [12] Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS
    Tang, Yiding
    Yu, Yue
    Li, Ranran
    Tao, Zheying
    Zhang, Li
    Wang, Xiaoli
    Qi, Xiaoling
    Li, Yinjiaozhi
    Meng, Tianjiao
    Qu, Hongping
    Zhou, Mi
    Xu, Jing
    Liu, Jialin
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [13] Extracellular histones aggravate inflammation in ARDS by promoting alveolar macrophage pyroptosis
    Jiang, Ping
    Jin, Yang
    Sun, Meng
    Jiang, Xuemei
    Yang, Jie
    Lv, Xin
    Wen, Zongmei
    MOLECULAR IMMUNOLOGY, 2021, 135 : 53 - 61
  • [14] Epidemiology of ARDS and ALI
    Blank, Ross
    Napolitano, Lena M.
    CRITICAL CARE CLINICS, 2011, 27 (03) : 439 - +
  • [15] Definition of ALI/ARDS
    Raghavendran, Krishnan
    Napolitano, Lena M.
    CRITICAL CARE CLINICS, 2011, 27 (03) : 429 - +
  • [16] Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment
    Liu, Chang
    Xiao, Kun
    Xie, Lixin
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [17] Ventilatory management of ALI/ARDS
    MacIntyre, Neil
    SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 27 (04) : 396 - 403
  • [18] Gene Therapy for ALI/ARDS
    Lin, Xin
    Dean, David A.
    CRITICAL CARE CLINICS, 2011, 27 (03) : 705 - +
  • [19] Nutrition Therapy for ALI and ARDS
    Krzak, Anna
    Pleva, Melissa
    Napolitano, Lena M.
    CRITICAL CARE CLINICS, 2011, 27 (03) : 647 - +
  • [20] Unveiling the nexus: pyroptosis and its crucial implications in liver diseases
    Miao, Zeyu
    Zhang, Xiaorong
    Xu, Yang
    Liu, Yan
    Yang, Qing
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, : 2159 - 2176
12345