Macrophage pyroptosis and its crucial role in ALI/ARDS

被引：0
|
作者：
Cai, Yuju [1 ,2 ]
Shang, Luorui [1 ]
Zhou, Fangyuan [1 ]
Zhang, Mengqi [1 ]
Li, Jinxiao [1 ]
Wang, Shuhan [1 ]
Lin, Qifeng [1 ]
Huang, Jianghua [1 ]
Yang, Shenglan [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Clin Nutr, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷
基金：
中国国家自然科学基金;
关键词：
ALI (acute lung injury); ARDS (acute respiratory distress syndrome); pyroptosis; macrophage; -; cell; treatment; ACUTE RESPIRATORY-DISTRESS; ACUTE LUNG INJURY; NEUTROPHIL EXTRACELLULAR TRAPS; INNATE IMMUNE RECOGNITION; NF-KAPPA-B; INFLAMMASOME ACTIVATION; GASDERMIN D; ASC; MITOCHONDRIA; CASPASES;
D O I：
10.3389/fimmu.2025.1530849
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI/ARDS and provide novel insights for its treatment.
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页数：16
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