Electroclinical Features of Infantile Epileptic Spasms Syndrome

被引:0
|
作者
Erdemir, Gozde [1 ]
Moosa, Ahsan N. [2 ]
机构
[1] Univ Maryland, Sch Med, Med Ctr, Dept Neurol, Baltimore, MD 21201 USA
[2] Cleveland Clin, Neurol Inst, Pediat Epilepsy Sect, Epilepsy Ctr, Cleveland, OH USA
关键词
Epileptic spasms; infantile spasms; hypsarrhythmia; West syndrome; HIGH-FREQUENCY OSCILLATIONS; WEST-SYNDROME; SLOW WAVES; HYPSARRHYTHMIA; CHILDREN; SEIZURES; ONSET; DIAGNOSIS; ETIOLOGY; CLUSTERS;
D O I
10.4103/aian.aian_445_24
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Epileptic spasms are a unique, age-dependent manifestation of epilepsies in infancy and early childhood, commonly occurring as part of infantile epileptic spasms syndrome. Developmental stagnation and subsequent decline may occur in children with epileptic spasms, partly due to the abundant high-amplitude interictal epileptiform and slow wave abnormalities. Early recognition and treatment of epileptic spasms, along with the reversal of the electroencephalography (EEG) findings, are critical for improving outcomes. Recognizing hypsarrhythmia and its variations is key to confirming the diagnosis. The various patterns of hypsarrhythmia are not etiology specific, but could indicate the severity of the disease. Several scoring systems have been proposed to improve the inter-rater reliability of recognizing hypsarrhythmia and to assess EEG progress in response to treatment. Ictal patterns during spasms are brief and composed of slow waves, sharp transients, fast activity, and voltage attenuation, either in isolation or more commonly as a combination of these waveforms. Ictal patterns are commonly diffuse, but may be lateralized to one hemisphere in children with structural etiology. A subset of patients with epileptic spasms has a surgically remediable etiology, with readily identifiable lesions on neuroimaging in most cases. Asymmetry in epileptic spasms, concurrent focal seizures, and asymmetric interictal and ictal EEG findings may be present, but a lack of focality in electrophysiological findings is not uncommon. Intracranial EEG features of epileptic spasms have been described, but the utility of intracranial EEG monitoring in surgical candidates with overt focal epileptogenic lesions on magnetic resonance imaging is questionable, and surgery could be performed using noninvasive data.
引用
收藏
页码:227 / 235
页数:9
相关论文
共 50 条
  • [41] INFANTILE SPASMS IN AICARDI SYNDROME
    CHEVRIE, JJ
    BRAIN & DEVELOPMENT, 1987, 9 (04): : 429 - 429
  • [42] Short-Term Effectiveness and Tolerability of Vigabatrin Therapy in Infantile Epileptic Spasms Syndrome
    Sharma, Shikha
    Dhir, Pooja
    Negi, Sandeep
    Pal, Pankaj
    Suthar, Renu
    Saini, Arushi
    Medhi, Bikash
    Sankhyan, Naveen
    Sahu, Jitendra K.
    INDIAN JOURNAL OF PEDIATRICS, 2025, : 398 - 401
  • [43] INFANTILE SPASMS - AN EARLY EPILEPTIC MANIFESTATION IN SOME PATIENTS WITH THE CONGENITAL BILATERAL PERISYLVIAN SYNDROME
    KUZNIECKY, R
    ANDERMANN, F
    GUERRINI, R
    JOURNAL OF CHILD NEUROLOGY, 1994, 9 (04) : 420 - 423
  • [44] INFANTILE SPASMS IN COFS SYNDROME
    HARDEN, CL
    TUCHMAN, AJ
    DARAS, M
    PEDIATRIC NEUROLOGY, 1991, 7 (04) : 302 - 304
  • [45] Williams Syndrome with Infantile Spasms
    Polat, Ipek
    Karaoglu, Pakize
    Ayanoglu, Muge
    Yis, Uluc
    Hiz, Semra
    INDIAN JOURNAL OF PEDIATRICS, 2015, 82 (08): : 757 - 758
  • [46] Long-term outcomes of children with infantile epileptic spasms syndrome in South Korea
    Choi, S. A.
    Kim, M-J
    Yum, M-S
    Kim, M.
    Kim, H. J.
    Kim, W. J.
    Lim, B. C.
    Han, J. Y.
    Kim, H.
    Woo, H.
    Kim, J. S.
    Lee, J.
    Lee, J.
    EPILEPSIA, 2023, 64 : 557 - 558
  • [47] Elementary school enrollment after ACTH therapy for patients with infantile epileptic spasms syndrome
    Matsuura, Ryuki
    Hamano, Shin-ichiro
    Hirata, Yuko
    Oba, Azusa
    Horita, Haruhito
    Takeuchi, Hirokazu
    Koichihara, Reiko
    Kikuchi, Kenjiro
    Oka, Akira
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2025, 124 : 80 - 84
  • [48] Electrographic screening for infantile epileptic spasms syndrome in a single sleep-wake cycle
    Mason, John A.
    Juarez-Colunga, Elizabeth
    Knupp, Kelly G.
    EPILEPSIA, 2024, 65 (06) : 1737 - 1743
  • [49] The landscape of infantile epileptic spasms syndrome in South Asia: peculiarities, challenges, and way forward
    Sahu, Jitendra Kumar
    Madaan, Priyanka
    Prakash, Kiran
    LANCET REGIONAL HEALTH - SOUTHEAST ASIA, 2023, 12
  • [50] A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome
    Mytinger, John R.
    Albert, Dara V. F.
    Aylward, Shawn C.
    Beatty, Christopher W.
    Bhalla, Sonam
    Bhatia, Sonal
    Brock, Guy N.
    Ciliberto, Micheal A.
    Choudhari, Purva R.
    Clark, Daniel J.
    Cohen, Jennifer Madan
    Czech, Theresa M.
    Fredwall, Megan M.
    Gonzalez-Giraldo, Ernesto
    Harini, Chellamani
    Hunter, Senyene E.
    Sandoval Karamian, Amanda G.
    Katyayan, Akshat
    Kistler, Isaac
    Kulkarni, Neil
    Liu, Virginia B.
    Mccabe, Corinne
    Murray, Thomas
    Neville, Kerri
    Patel, Shital H.
    Pavuluri, Spriha
    Phillips, Donald J.
    Samanta, Debopam
    Sirsi, Deepa
    Spelbrink, Emily M.
    Stafstrom, Carl E.
    Steenari, Maija
    Takacs, Danielle S.
    Terrill, Tyler
    Tran, Linh
    Vidaurre, Jorge
    Shrey, Daniel W.
    JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2025, 42 (03) : 230 - 234