Anti-inflammatory effects of PDE3/4 inhibitor ensifentrine in peripheral blood mononuclear cells from COPD patients

被引:0
|
作者
Lea, Simon [1 ]
Li, Jian [1 ]
Littolf, Kieran [1 ]
Vijayacumaran, Kajaluckcika [1 ]
Singh, Dave [1 ]
机构
[1] Univ Manchester, Manchester, England
关键词
D O I
10.1183/13993003.congress-2024.OA2775
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Anti-inflammatory effect of a novel inhaled dual PDE3/4 inhibitor RPL554 in man, a unique "first-in-class" drug for the treatment of COPD & asthma
    Singh, Dave
    Reid, Fred
    Franciosi, Lui
    Walker, Michael
    Page, Clive
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [22] Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases
    Abbott-Banner, Katharine H.
    Page, Clive P.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 114 (05) : 365 - 376
  • [23] Safety And Bronchodilator Effects Of Nebulized Rpl554, A Novel Dual Pde3/4 Inhibitor In COPD
    Cazzola, M.
    Calzetta, L.
    Segreti, A.
    Rogliani, P.
    Page, C.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [24] Ensifentrine, a dual PDE3/PDE4 inhibitor, improves FEV1 regardless of smoking status or history of chronic bronchitis
    Rheault, Tara
    Bengtsson, Thomas
    Rickard, Kathleen
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [25] Treatment With Ensifentrine, a Dual PDE3 and PDE4 Inhibitor, Significantly Reduced Exacerbation Rate and Risk in Subjects With COPD: Sub-group Results From the Phase 3 Trial, Enhance-2
    Anzueto, A.
    Rheault, T.
    Bengtsson, T.
    Rickard, K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
  • [26] Toll like receptor 4 mediates the anti-inflammatory effect of metformin in human peripheral blood mononuclear cells
    Coppola, A.
    Della Morte, D.
    Tartaglione, S.
    Caputol', M.
    Capuamn, B.
    Pacifici, F.
    Arriga, R.
    Pastore, D.
    Caratelli, S.
    Ferrazzoli, V.
    Bellia, A.
    Federici, M.
    Sbraccia, P.
    Sconocchia, G.
    Lauro, D.
    DIABETOLOGIA, 2016, 59 : S278 - S278
  • [27] Anti-inflammatory effects of infliximab and methotrexate on peripheral blood and synovial fluid mononuclear cells: ex vivo study
    Gertel, S.
    Rokach, M.
    Polachek, A.
    Litinsky, I
    Anouk, M.
    Elkayam, O.
    Furer, V
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2024, 53 (03) : 188 - 198
  • [28] Safety of Ensifentrine, a Dual PDE3/4 Inhibitor: Results of Reported GI and CV Events from a Four Week Randomized, Controlled Trial
    Rickard, K.
    Rheault, T.
    Bengtsson, T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [29] Anti-inflammatory action of geopropolis produced by stingless bees on human peripheral blood mononuclear cells
    Honorio, Mariana da Silva
    Sartori, Arthur Alves
    Ripari, Nicolas
    Santiago, Karina Basso
    Sforcin, Jose Mauricio
    HUMAN IMMUNOLOGY, 2024, 85 (04)
  • [30] Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells
    Lu, Junying
    Fang, Keyong
    Wang, Shiji
    Xiong, Lingxin
    Zhang, Chao
    Liu, Zhongmin
    Guan, Xuewa
    Zheng, Ruipeng
    Wang, Guoqiang
    Zheng, Jingtong
    Wang, Fang
    MEDIATORS OF INFLAMMATION, 2018, 2018