A Role for Germline Variants in Multiple Myeloma?

被引：0
|
作者：
Walker, Brian A. [1 ]
机构：
[1] Indiana Univ Sch Med, Melvin & Bren Simon Comprehens Canc Ctr, Div Hematol & Oncol, Indianapolis, IN USA
来源：
BLOOD CANCER DISCOVERY | 2024年 / 5卷 / 06期
关键词：
D O I：
10.1158/2643-3230.BCD-24-0226
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In Blood Cancer Discovery, Thibaud and colleagues report the incidence of pathogenic germline variants (PGV) in patients with multiple myeloma and that these PGVs are associated with DNA repair pathway genes, including BRCA1 and BRCA2. They find an association of patients with PGVs and previous family or personal history of cancer, and that these patients are diagnosed slightly earlier than those without PGVs. Patients with PGVs had a longer progression-free survival than those without PGVs when they received high-dose melphalan and autologous stem cell transplant, providing a therapeutic rationale for diagnostic germline testing in myeloma. See related article by Thibaud et al., p. 428
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收藏
页码：375 / 376
页数：2
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