Inter-membrane control of junctional InsP3 receptors by PIP2

被引:0
|
作者
Zhou, Yandong [1 ]
Wang, Youjun [2 ]
Gill, Donald L. [1 ]
机构
[1] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA
[2] Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resources & Mol Dev, Beijing 100875, Peoples R China
关键词
IP3; RECEPTORS;
D O I
10.1016/j.tcb.2024.11.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca2+ signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP2) reaches across plasma membrane (PM)-endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca2+ signals mediating a spectrum of fundamental cellular responses.
引用
收藏
页码:1 / 3
页数:3
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