Targeting DKK1 to Remodel the Tumor Microenvironment and Enhance Immune Checkpoint Blockade Therapy

被引：0
|
作者：
Shi, Tao [1 ]
Wei, Jia [1 ]
机构：
[1] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp,Med Sch, Dept Oncol, Nanjing, Peoples R China
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2025年 / 43卷 / 03期
基金：
中国国家自然科学基金;
关键词：
PLUS CHEMOTHERAPY; GASTROESOPHAGEAL JUNCTION; SERUM DICKKOPF-1; BIOMARKER; CANCER; ANTAGONIST; DIAGNOSIS; CELLS; LUNG;
D O I：
10.1200/JCO-24-01619
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：5
相关论文
共 50 条
  • [31] Antibody mediated blockade of phosphatidylserine improves immune checkpoint blockade by repolarizing immune suppressive mechanisms of the tumor microenvironment
    Hutchins, J.
    ANNALS OF ONCOLOGY, 2016, 27
  • [32] Irradiated engineered tumor cell-derived microparticles remodel the tumor immune microenvironment and enhance antitumor immunity
    Hu, Yan
    Sun, Yajie
    Liao, Zhiyun
    An, Dandan
    Liu, Xixi
    Yang, Xiao
    Tian, Yu
    Deng, Suke
    Meng, Jingshu
    Wang, Yijun
    Li, Jie
    Deng, Yue
    Zhou, Zhiyuan
    Chen, Qinyan
    Ye, Ying
    Wei, Wenwen
    Wu, Bian
    Lovell, Jonathan F.
    Jin, Honglin
    Huang, Fang
    Wan, Chao
    Yang, Kunyu
    MOLECULAR THERAPY, 2024, 32 (02) : 411 - 425
  • [33] Immune-active microenvironment in SCCOHT: Rationale for therapy with immune checkpoint blockade.
    Van Oudenhove, Elke
    Jelinic, Petar
    Ricca, Jacob
    Narciso, Olvera
    Merghoub, Taha
    Levine, Douglas A.
    Zamarin, Dmitriy
    CLINICAL CANCER RESEARCH, 2018, 24 (15) : 95 - 95
  • [34] Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy
    Andersson, Patrik
    Ostheimer, Christian
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [35] Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade
    Genova, Carlo
    Dellepiane, Chiara
    Carrega, Paolo
    Sommariva, Sara
    Ferlazzo, Guido
    Pronzato, Paolo
    Gangemi, Rosaria
    Filaci, Gilberto
    Coco, Simona
    Croce, Michela
    FRONTIERS IN IMMUNOLOGY, 2022, 12
  • [36] Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade
    Son, Soyoung
    Shin, Jung Min
    Shin, Sol
    Kim, Chan Ho
    Lee, Jae Ah
    Ko, Hyewon
    Lee, Eun Sook
    Jung, Jae Min
    Kim, Jeongyun
    Park, Jae Hyung
    BIOMATERIALS, 2021, 276 (276)
  • [37] Distinct roles of DKK1 and DKK2 in tumor angiogenesis
    Hongryeol Park
    Hyei Yoon Jung
    Hyun-Jung Choi
    Dong Young Kim
    Ji-Young Yoo
    Chae-Ok Yun
    Jeong-Ki Min
    Young-Myoung Kim
    Young-Guen Kwon
    Angiogenesis, 2014, 17 : 221 - 234
  • [38] Reversing tumor immunosuppressive microenvironment via targeting codelivery of CpG ODNs/PD-L1 peptide antagonists to enhance the immune checkpoint blockade-based anti-tumor effect
    Zhang, Min
    Fang, Zhou
    Zhang, Haitao
    Cui, Mingxiao
    Wang, Mingfu
    Liu, Kehai
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 168
  • [39] Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
    Tianyu Tang
    Xing Huang
    Gang Zhang
    Zhengtao Hong
    Xueli Bai
    Tingbo Liang
    Signal Transduction and Targeted Therapy, 6
  • [40] Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
    Tang, Tianyu
    Huang, Xing
    Zhang, Gang
    Hong, Zhengtao
    Bai, Xueli
    Liang, Tingbo
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
12345