Promising Natural Remedies for Alzheimer's Disease Therapy

被引:0
|
作者
Thawabteh, Amin Mahmood [1 ,2 ]
Ghanem, Aseel Wasel [2 ]
Abumadi, Sara [2 ]
Thaher, Dania [2 ]
Jaghama, Weam [2 ]
Karaman, Donia [3 ]
Karaman, Rafik [3 ,4 ]
机构
[1] Birzeit Univ, Dept Chem, West Bank, Ramallah 00972, Palestine
[2] Birzeit Univ, Fac Pharm Nursing & Hlth Profess, West Bank, Ramallah 00972, Palestine
[3] Al Quds Univ, Fac Pharm, Pharmaceut Sci Dept, Jerusalem 20002, Palestine
[4] Univ Basilicata, Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy
来源
MOLECULES | 2025年 / 30卷 / 04期
关键词
Alzheimer's disease; anti-amyloid drugs; phytoconstituents; <italic>Ginkgo biloba</italic>; rosemary; BACOPA-MONNIERI; COGNITIVE IMPAIRMENT; DOUBLE-BLIND; EXTRACT; NEUROINFLAMMATION; DEMENTIA; PATHWAY; INFLAMMATION; RESVERATROL; POLYPHENOLS;
D O I
10.3390/molecules30040922
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study examines the intricacies of Alzheimer's disease (AD), its origins, and the potential advantages of various herbal extracts and natural compounds for enhancing memory and cognitive performance. Future studies into AD treatments are encouraged by the review's demonstration of the effectiveness of phytoconstituents that were extracted from a number of plants. In addition to having many beneficial effects, such as improved cholinergic and cognitive function, herbal medicines are also much less harmful, more readily available, and easier to use than other treatments. They also pass without difficulty through the blood-brain barrier (BBB). This study focused on natural substances and their effects on AD by using academic databases to identify peer-reviewed studies published between 2015 and 2024. According to the literature review, 66 phytoconstituents that were isolated from 21 distinct plants have shown efficacy, which could be encouraging for future research on AD therapies. Since most clinical trials produce contradictory results, the study suggests that larger-scale studies with longer treatment durations are necessary to validate or refute the therapeutic efficacy of herbal AD treatments.
引用
收藏
页数:39
相关论文
共 50 条
  • [21] Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy
    Chumakov, Ilya
    Nabirotchkin, Serguei
    Cholet, Nathalie
    Milet, Aude
    Boucard, Aurelie
    Toulorge, Damien
    Pereira, Yannick
    Graudens, Esther
    Traore, Sory
    Foucquier, Julie
    Guedj, Mickael
    Vial, Emmanuel
    Callizot, Noealle
    Steinschneider, Remy
    Maurice, Tangui
    Bertrand, Viviane
    Scart-Gres, Catherine
    Hajj, Rodolphe
    Cohen, Daniel
    SCIENTIFIC REPORTS, 2015, 5
  • [22] Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy
    Dakhlaoui, Imen
    Maalej, Emna
    Martin, Helene
    Lucht, Aurelia
    Iriepa, Isabel
    Moraleda, Ignacio
    Marco-Contelles, Jose
    Chabchoub, Fakher
    Ismaili, Lhassane
    CHEMISTRYSELECT, 2021, 6 (37): : 9975 - 9980
  • [23] Flotillin: A Promising Biomarker for Alzheimer's Disease
    Angelopoulou, Efthalia
    Paudel, Yam Nath
    Shaikh, Mohd. Farooq
    Piperi, Christina
    JOURNAL OF PERSONALIZED MEDICINE, 2020, 10 (02):
  • [24] Promising agents for treating Alzheimer's disease
    Simonson, W
    AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 1998, 55 : S11 - S16
  • [25] Alzheimer disease: primary ischemia concept and promising therapy
    Niedermeyer, E.
    Mazza, M.
    Mazza, S.
    CLINICA TERAPEUTICA, 2008, 159 (06): : 439 - 442
  • [26] A promising new treatment for Alzheimer's disease?
    O'Brien, John T.
    LANCET NEUROLOGY, 2008, 7 (09): : 768 - 769
  • [27] HERBAL REMEDIES FOR NEURODEGENERATIVE DISORDER (ALZHEIMER'S DISEASE): A REVIEW
    Agarwal, Parul
    Alok, Shashi
    Fatima, Amreen
    Singh, Prem Prakash
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (09): : 3328 - 3340
  • [28] Tacrine-Natural-Product Hybrids for Alzheimer's Disease Therapy
    Jesus Oset-Gasque, Maria
    Luis Marco-Contelles, Jose
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (26) : 4392 - 4400
  • [29] Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy
    Dgachi, Youssef
    Martin, Helene
    Bonet, Alexandre
    Chioua, Mourad
    Iriepa, Isabel
    Moraleda, Ignacio
    Chabchoub, Fakher
    Marco-Contelles, Jose
    Ismaili, Lhassane
    FUTURE MEDICINAL CHEMISTRY, 2017, 9 (08) : 715 - 721
  • [30] Natural Products as Promising Drug Candidates for the Treatment of Alzheimer's Disease: Molecular Mechanism Aspect
    Ansari, Niloufar
    Khodagholi, Fariba
    CURRENT NEUROPHARMACOLOGY, 2013, 11 (04) : 414 - 429