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Bridging the gap of vision restoration
被引:0
|作者:
Carleton, Maya
[1
]
Oesch, Nicholas W.
[1
,2
,3
]
机构:
[1] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Neurosci Grad Program, La Jolla, CA 92093 USA
关键词:
vision restoration;
retinal degeneration;
age related macular degeneration;
retinitis pigmentosa;
retinal prosthesis;
retina;
optogenetics;
AGE-RELATED MACULOPATHY;
COMPLEMENT FACTOR-H;
RD10 MOUSE MODEL;
MACULAR DEGENERATION;
RETINITIS-PIGMENTOSA;
OXIDATIVE STRESS;
RETINAL DEGENERATION;
CARDIOVASCULAR-DISEASE;
GLOBAL PREVALENCE;
VISUAL FUNCTION;
D O I:
10.3389/fncel.2024.1502473
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Retinitis pigmentosa (RP) and Age-Related Macular Degeneration (AMD) are similar in that both result in photoreceptor degeneration leading to permanent progressive vision loss. This affords the possibility of implementing vision restoration techniques, where light signaling is restored to spared retinal circuitry to recreate vision. There are far more AMD patients (Wong et al., 2014), yet more resources have been put towards researching and developing vision restoration strategies for RP despite it rarity, because of the tractability of RP disease models. The hope is that these therapies will extend to the AMD population, however, many questions remain about how the implementation of prosthetic or optogenetic vision restoration technologies will translate between RP and AMD patients. In this review, we discuss the difference and similarities of RP and AMD with a focus on aspects expected to impact vision restoration strategies, and we identify key gaps in knowledge needed to further improve vision restoration technologies for a broad patient population.
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