New 14,15-dinor-neo-clerodane and neo-clerodane diterpenoids from Ajuga macrosperma Wall. ex benth

被引：0

作者：

Li, Yi-huan ^{[1
]}

Ba, Yi-hang ^{[1
]}

Xiao, Jian-fen ^{[1
]}

Chen, Shuai ^{[1
]}

Zhu, Tian-qing ^{[1
,2
]}

Liu, Kai-xiang ^{[1
]}

He, Hong-ping ^{[1
]}

Jiang, Hua-yi ^{[1
]}

Yang, Rui ^{[1
]}

机构：

[1] Yunnan Univ Chinese Med, Coll Chinese Mat Med, Yunnan Key Lab Southern Med Utilizat, Kunming, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Nat Med, Kunming, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

关键词：

Ajuga macrosperma; 14,15-dinor-neo-clerodane diterpenoid; neo-clerodane diterpenoid; anti-inflammatory activity; antibacterial activity; CLERODANE DITERPENES;

D O I：

10.1080/14786419.2025.2473573

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new diterpenoid possessing a rare 14,15-dinor-neo-clerodane framework, ajugamacrin H (1), and one new neo-clerodane diterpenoid, ajugamacrin I (2), along with seven known analogues (3-9), were obtained from Ajuga macrosperma Wall. ex Benth.. Structures of compounds 1 and 2 were elucidated primarily based on NMR and MS methods, and their absolute configurations were identified via ECD calculations. 3, 7, and 8 exhibited inhibitory activities on NO production in LPS-stimulated RAW 264.7 cells at 50 mu M. Moreover, compounds 1-9 were evaluated for their antibacterial effects against four strains of bacteria.

引用

页数：5

共 50 条

[21] Neo-clerodane diterpenoids from Scutellaria lateriflora
Bruno, M
Cruciata, M
Bondi, ML
Piozzi, F
de la Torre, MC
Rodríguez, B
Servettaz, O
PHYTOCHEMISTRY, 1998, 48 (04) : 687 - 691
[22] Neo-clerodane diterpenoids from Scutellaria galericulata
Rodriguez, B
DelaTorre, MC
Rodriguez, B
GomezSerranillos, P
PHYTOCHEMISTRY, 1996, 41 (01) : 247 - 253
[23] Neo-clerodane diterpenoids from Scutellaria alpina
Malakov, PY
Papanov, GY
PHYTOCHEMISTRY, 1998, 49 (08) : 2449 - 2452
[24] neo-Clerodane diterpenoids from Teucrium alyssifolium
Topcu, G
Eris, C
Ulubelen, A
JOURNAL OF NATURAL PRODUCTS, 1997, 60 (10): : 1045 - 1047
[25] neo-Clerodane Diterpenoids from Scutellaria galericulata
Bozov, Petko I.
Penchev, Plamen N.
Coll, Josep
NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (03) : 347 - 350
[26] Neo-clerodane diterpenoids from Clerodendrum inerme
Pandey, R
Verma, RK
Gupta, MM
PHYTOCHEMISTRY, 2005, 66 (06) : 643 - 648
[27] Neo-clerodane diterpenoids from Teucrium sandrasicum
delaTorre, MC
Rodriguez, B
Bruno, M
Fazio, C
Baser, KHC
Duman, H
PHYTOCHEMISTRY, 1997, 45 (08) : 1653 - 1662
[28] Neo-clerodane diterpenoids from Teucrium polium
Bedir, E
Tasdemir, D
Çalis, I
Zerbe, O
Sticher, O
PHYTOCHEMISTRY, 1999, 51 (07) : 921 - 925
[29] Neo-clerodane diterpenoids from Croton schiedeanus
Puebla, P
López, JL
Guerrero, M
Carrón, R
Martín, ML
San Román, L
San Feliciano, A
PHYTOCHEMISTRY, 2003, 62 (04) : 551 - 555
[30] Ajugatansins, neo-clerodane diterpenes from Ajuga reptans
Carbonell, P
Coll, J
PHYTOCHEMICAL ANALYSIS, 2001, 12 (01) : 73 - 78

← 1 2 3 4 5 →