Asymmetric Halocyclization of 2-Anilidostyrenes Using N-Haloamides Enabled by Chiral Anion Phase-Transfer Catalysis

被引：0

作者：

Zhang, Penglei ^{[1
]}

Du, Xue ^{[1
]}

Tu, Guogang ^{[1
]}

Sun, Yanji ^{[1
]}

Xiong, Xiaodong ^{[1
]}

机构：

[1] Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China

来源：

ORGANIC LETTERS | 2025年

基金：

中国国家自然科学基金;

关键词：

INHIBITORS; FLUORINE; ALCOHOLS; POTENT;

D O I：

10.1021/acs.orglett.5c00887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric halogenation for efficient construction of various 4H-3,1-benzoxazine derivatives with excellent functional group tolerance using readily available N-haloamides as the halogen source and ammonium phosphate salt catalyst under mild reaction conditions has been developed. The ammonium salt catalyst loading could be reduced to 1 mol % and recycled 4 times without deterioration in reactivity and stereoselectivity. Importantly, this process features a column-purification-free operation, leading to the green and atom-economical preparation of chiral benzoxazines in good to excellent yields and high enantioselectivities.

引用

页数：6

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