Carnosic acid prevents heat stress-induced oxidative damage by regulating heat-shock proteins and apoptotic proteins in mouse testis

被引：0
|
作者：
Liu, Sirui [1 ]
Liang, Wanqing [1 ]
Liu, Yinkun [1 ]
Wan, Shuangshuang [1 ]
Tang, Shu [1 ]
机构：
[1] Nanjing Agr Univ, Coll Vet Med, 1 Weigang, Nanjing 210095, Peoples R China
来源：
BIOLOGICAL CHEMISTRY | 2024年
基金：
中国国家自然科学基金;
关键词：
carnosic acid; Hsp70; heat stress; apoptosis; knockout mice; INJURY; MILD;
D O I：
10.1515/hsz-2023-0374
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heat stress impacts male reproduction in animal husbandry. Carnosic acid (CA), a potent antioxidant, mitigates oxidative stress and apoptosis. alpha B-crystallin, a small heat shock protein, regulates apoptosis and oxidative stress. This study examines the protective effects of CA on the testis in wild-type and alpha B-crystallin knockout mice under heat stress. CA pretreatment increased testosterone levels and preserved testicular structure in wild-type mice, but no changes in knockout mice. CA reduced Hsp27, Hsp70, and cleaved caspase-3 levels, while knockout mice showed increased cleaved caspase-3. These results suggest that CA protects the testis by modulating heat shock and apoptosis-related proteins.
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页数：5
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