Ligand-Promoted Remote γ-C(sp3)-H Chlorination and Bromination of Alcohols

被引：0

作者：

Tu, Yang-Yang ^{[1
]}

Luo, Jun ^{[1
]}

Jiang, Chao ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem & Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; C(SP(3))-H BONDS; PD(II)-CATALYZED BROMINATION; DIRECTING-GROUP; HALOGENATION; AMINATION; AMINE; ACIDS;

D O I：

10.1021/acs.joc.4c03031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a Pd(II)-catalyzed protocol f-C(sp3)-H chlorination and bromination of aliphatic alcohols using NCS and NBS as the halogenating reagents. The addition of 2-pyridone ligand and base was crucial to the success of the reaction. The method showed excellent functional group tolerance. The gram-scale reaction and the facile removal of the directing group demonstrated its potential application in the synthesis of gamma-chloro or bromo alcohols containing quaternary carbon.

引用

页数：10

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