The dual function of autophagy in doxorubicin-induced cardiotoxicity: Mechanism and natural products

被引：0

作者：

Tan, Nannan ^{[1
,2
]}

Luo, Hanwen ^{[1
]}

Li, Weili ^{[1
]}

Ling, Guanjing ^{[1
]}

Wei, Yan ^{[1
]}

Wang, Wei ^{[1
,3
,4
,5
]}

Wang, Yong ^{[6
]}

机构：

[1] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China

[2] Anhui Univ Chinese Med, Hefei 230012, Peoples R China

[3] Guangzhou Univ Chinese Med, Guangzhou 510006, Peoples R China

[4] Beijing Univ Chinese Med, Beijing Key Lab TCM Syndrome & Formula, Beijing 100029, Peoples R China

[5] Beijing Univ Chinese Med, Key Lab TCM Syndrome & Formula, Minist Educ, Beijing 100029, Peoples R China

[6] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100029, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2025年 / 109卷

基金：

中国国家自然科学基金;

关键词：

Doxorubicin-induced cardiotoxicity; Autophagy; Natural products; Cardio-oncology; ANTHRACYCLINE CARDIOTOXICITY; CARDIOMYOCYTE DEATH; OXIDATIVE STRESS; DYSFUNCTION; INHIBITION; APOPTOSIS; CELLS;

D O I：

10.1016/j.semcancer.2025.01.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Doxorubicin (DOX) is an anthracycline antitumor drug discovered in 1969, which can care for leukemia, breast cancer, lymphoma, and sarcoma. However, cardiotoxicity induced by DOX seriously limits its clinical value. The etiopathogenesis and therapeutic strategies are not unified. Autophagy is a critical mechanism in the progression of DOX-induced cardiotoxicity (DIC), autophagy intervention is a potential therapeutic strategy for DIC. Natural product has been considered as a complementary and alternative approach to treat cardiovascular disease. In this review, we summarize the pathology of autophagy in DIC and the natural products for DIC therapy.

引用

页码：83 / 90

页数：8

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