Bone marrow immune cells and drug resistance in acute myeloid leukemia

被引：0
|
作者：
Zhang, Miao [1 ,2 ]
Yang, You [1 ,2 ]
Liu, Jing [1 ,2 ]
Guo, Ling [1 ,2 ]
Guo, Qulian [1 ,2 ]
Liu, Wenjun [1 ,2 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Pediat Hematol Oncol, Children Hematol Oncol & Birth Defects Lab, Luzhou, Sichuan, Peoples R China
[2] Southwest Med Univ, Sichuan Clin Res Ctr Birth Defects, Affiliated Hosp, Luzhou, Sichuan, Peoples R China
来源：
EXPERIMENTAL BIOLOGY AND MEDICINE | 2025年 / 250卷
关键词：
leukemia; immune cells; drug resistance; bone marrow; immunosuppressive microenvironment; REGULATORY T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; POOR-PROGNOSIS; NK CELLS; AML CELLS; IN-VITRO; EXPRESSION; ACTIVATION; INDUCTION;
D O I：
10.3389/ebm.2025.10235
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), along with the dysfunction and exhaustion of immunological effector cells, including cytotoxic T lymphocytes (CTLs), dendritic cells (DCs) and natural killer cells (NKs), can induce immune escape of leukemia cells and are closely linked to therapy resistance in leukemia. This article reviews the research progress on the relationship between immune cells in the marrow microenvironment and chemoresistance in AML, aiming to provide new ideas for the immunotherapy of AML.
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页数：17
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