The roots of the Institut Pasteur's "Grand Cours"

The article presents an analysis of the history of the microbiology course delivered during the inaugural operational year of the Institut Pasteur in Paris. The year 1889 is examined through the lens of three hitherto unknown volumes that bring together the microbiology lectures delivered at the end of the 19th century. The course was entirely independent from the teaching provided by the universities or faculties of medicine and rapidly gained international recognition. Indeed, the course provided the students with the theoretical knowledge of Pasteurian theories regarding the completely new discipline of microbiology and the specific techniques used to cultivate, conserve, and observe microbes. The steady increase in the number of lectures between 1889 and 1914 reflects the expansion of microbiological knowledge during this period. The contributions of researchers such as E<acute accent>mile Roux (1853-1933), E<acute accent>lie Metchnikoff (1845-1916), and Ame<acute accent>de<acute accent>e Borrel (1867-1936) illuminated the collaboration and the growing diversification of expertise at the heart of the Institut Pasteur (IP). Furthermore, this study highlights the international influence of the course, as evidenced by the participation of foreign students. It examines the history of the course as a powerful tool for disseminating knowledge of new microbiological techniques and the results of research carried out in Pasteur's laboratories. It also examines how the course served as a political instrument, asserting the authority of the Institut Pasteur in the field of microbiology in France and extending its influence worldwide.