HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation
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作者:
Hu, Xin
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机构:
Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Hu, Xin
[1
]
Zhang, Sijia
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机构:
Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Zhang, Sijia
[1
]
Zhang, Xiaoyu
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机构:
Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Zhang, Xiaoyu
[1
]
Liu, Hongyan
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机构:
Shandong First Med Univ, Jinan Cent Hosp, Res Ctr Basic Med, Jinan 250013, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Liu, Hongyan
[2
]
Diao, Yutao
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机构:
Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Diao, Yutao
[1
]
Li, Lianlian
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机构:
Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Shandong First Med Univ, Dept Oncol, Shandong Prov Hosp, 324 Jingwu Weiqi Rd, Jinan 250021, Shandong, Peoples R ChinaShandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
Li, Lianlian
[1
,3
]
机构:
[1] Shandong First Med Univ, Sch Clin & Basic Med Sci, Dept Immunol, Jinan 250117, Shandong, Peoples R China
[2] Shandong First Med Univ, Jinan Cent Hosp, Res Ctr Basic Med, Jinan 250013, Shandong, Peoples R China
[3] Shandong First Med Univ, Dept Oncol, Shandong Prov Hosp, 324 Jingwu Weiqi Rd, Jinan 250021, Shandong, Peoples R China
homeobox D1;
lung cancer;
DNA methylation;
DNA methyltransferase;
biomarker;
BONE MORPHOGENETIC PROTEINS;
CANCER;
EXPRESSION;
GENES;
PROLIFERATION;
PROMOTER;
ROLES;
D O I:
10.3892/or.2024.8832
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The homeobox (HOX) gene family encodes a number of highly conserved transcription factors and serves a crucial role in embryonic development and tumorigenesis. Homeobox D1 (HOXD1) is a member of the HOX family, whose biological functions in lung cancer are currently unclear. The University of Alabama at Birmingham Cancer data analysis Portal of HOXD1 expression patterns demonstrated that HOXD1 was downregulated in lung adenocarcinoma (LUAD) patient samples compared with adjacent normal tissue. Western blotting analysis demonstrated low HOXD1 protein expression levels in lung LUAD cell lines. The Kaplan-Meier plotter database demonstrated that reduced HOXD1 expression levels in LUAD correlated with poorer overall survival. Meanwhile, an in vitro study showed that HOXD1 overexpression suppressed LUAD cell proliferation, migration and invasion. In a mouse tumor model, upregulated HOXD1 was demonstrated to inhibit tumor growth. In addition, targeted bisulfite sequencing and chromatin immunoprecipitation assays demonstrated that DNA hypermethylation occurred in the promoter region of the HOXD1 gene and was associated with the action of DNA methyltransferases. Moreover, upregulated HOXD1 served as a transcriptional factor and increased the transcriptional expression of bone morphogenic protein (BMP)2 and BMP6. Taken together, the dysregulation of HOXD1 mediated by DNA methylation inhibited the initiation and progression of LUAD by regulating the expression of BMP2/BMP6.
机构:
Chiba Univ, Grad Sch Med, Mol Oncol, Chiba, Japan
Chiba Univ, Grad Sch Med, Gen Thorac Surg, Chiba, JapanChiba Univ, Grad Sch Med, Mol Oncol, Chiba, Japan
Ito, Yuki
Matsusaka, Keisuke
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Chiba Univ, Grad Sch Med, Mol Oncol, Chiba, JapanChiba Univ, Grad Sch Med, Mol Oncol, Chiba, Japan
Matsusaka, Keisuke
Usui, Genki
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机构:
Chiba Univ, Grad Sch Med, Mol Oncol, Chiba, JapanChiba Univ, Grad Sch Med, Mol Oncol, Chiba, Japan
机构:
Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Pediat Translat Med Inst, Sch Med, Shanghai, Peoples R China
Shanghai Jiao Tong Univ, Chongming Branch, Sch Med, Xinhua Hosp, Shanghai, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Shen, Nan
Du, Jun
论文数: 0引用数: 0
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机构:
Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Diagnost Imaging Ctr, Shanghai, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Du, Jun
Zhou, Hui
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机构:
Cent South Univ, Xiangya Sch Med, Tumor Hosp, Lymphoma & Hematol Dept, Changsha, Hunan, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Zhou, Hui
Chen, Nan
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机构:
Shanghai Jiao Tong Univ, Chongming Branch, Sch Med, Xinhua Hosp, Shanghai, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Chen, Nan
Pan, Yi
论文数: 0引用数: 0
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机构:
German Canc Res Ctr, Div Funct Genome Anal, Heidelberg, Germany
Heidelberg Univ, Fac Med Heidelberg, Heidelberg, GermanyShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Pan, Yi
Hoheisel, Jorg D.
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German Canc Res Ctr, Div Funct Genome Anal, Heidelberg, GermanyShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Hoheisel, Jorg D.
Jiang, Zonghui
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机构:
First Peoples Hosp, Dept Med Oncol, Chuzhou, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Jiang, Zonghui
Xiao, Ling
论文数: 0引用数: 0
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机构:
Cent South Univ, Sch Basic Med Sci, Dept Histol & Embryol, Changsha, Hunan, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Xiao, Ling
Tao, Yue
论文数: 0引用数: 0
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机构:
Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Pediat Translat Med Inst, Sch Med, Shanghai, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
Tao, Yue
Mo, Xi
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Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Pediat Translat Med Inst, Sch Med, Shanghai, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Infect Dis, Sch Med, Shanghai, Peoples R China
机构:
Fujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R China
Wang, Haidao
Hu, Yiming
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机构:
Fujian Med Univ, Fuzhou 350108, Fujian, Peoples R China
Natl Ctr Chron & Noncommunicable Dis Control & Pre, Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R China
Hu, Yiming
Lu, Haibin
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机构:
Fujian Med Univ, Fuzhou 350108, Fujian, Peoples R China
Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R China
Lu, Haibin
Wu, Zhijie
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机构:
Fujian Med Univ, Fuzhou 350108, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R China
Wu, Zhijie
Zhang, Yixiang
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机构:
Fujian Med Univ, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Quanzhou 362000, Fujian, Peoples R China
机构:
Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Wang, Shuang
Liu, Ximeng
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Liu, Ximeng
Zhou, Ting
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Immunol, Zhongshan Sch Med, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Zhou, Ting
Li, Jinling
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Li, Jinling
Lin, Ying
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Immunol, Zhongshan Sch Med, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Lin, Ying
Zhou, Anni
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Zhou, Anni
Huang, Jiamin
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h-index: 0
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Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Huang, Jiamin
Zhao, Jingjing
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h-index: 0
机构:
Sun Yat Sen Univ, Dept Cardiac Surg Ctr, Affiliated Hosp 1, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Zhao, Jingjing
Cai, Junchao
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h-index: 0
机构:
Sun Yat Sen Univ, Dept Immunol, Zhongshan Sch Med, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Cai, Junchao
Cai, Xiuyu
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Gen Internal Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Cai, Xiuyu
Huang, Yongbo
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h-index: 0
机构:
Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou 510060, Peoples R China
Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Affiliated Hosp 1, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China
Huang, Yongbo
Li, Xu
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Peoples R China