Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice

被引:0
|
作者
Li, Daoyong [1 ,2 ]
Bai, Mingyu [1 ,2 ]
Guo, Zhanpeng [2 ]
Cui, Yang [1 ,2 ]
Mei, Xifan [1 ,2 ]
Tian, He [2 ,3 ]
Shen, Zhaoliang [1 ]
机构
[1] Jinzhou Med Univ, Affiliated Hosp 3, Jinzhou City, Liaoning, Peoples R China
[2] Key Lab Liaoning Med Org Engn, Jinzhou, Liaoning, Peoples R China
[3] Jinzhou Med Univ, Sch Basic Med, Jinzhou, Liaoning, Peoples R China
基金
中国国家自然科学基金;
关键词
spinal cord injury; zinc; microglial polarization; inflammatory response; functional recovery; NF-KAPPA-B; PATHWAY;
D O I
10.3389/fphar.2025.1510372
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction Spinal cord injury (SCI) leads to severe inflammation and neuronal damage, resulting in permanent loss of motor and sensory functions. Zinc ions have shown potential in modulating inflammation and cellular survival, making them a promising therapeutic approach for SCI. This study investigates the mechanisms of zinc ion treatment in SCI, focusing on its effects on inflammation.Methods We used transcriptomic analysis to identify key pathways and genes involved in the inflammatory response in a mouse model of SCI. In vitro studies assessed the impact of zinc ions on inflammation, cell polarization, and apoptosis. IKB alpha expression was evaluated as a potential target of zinc ions, both in cultured cells and in vivo.Results Transcriptomic analysis revealed that zinc ions modulate inflammatory pathways through IKB alpha, which inhibits NF-kappa B activity. In vitro, zinc treatment upregulated IKB alpha expression, reducing inflammation, polarization, and apoptosis. These results were confirmed in the SCI mouse model, where zinc ions also reduced inflammation and cell death.Discussion Our findings highlight a novel mechanism by which zinc ions regulate inflammation in SCI by upregulating IKB alpha and inhibiting NF-kappa B activation. This suggests potential therapeutic applications of zinc ions in SCI and other inflammatory conditions, warranting further investigation into their clinical benefits.
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页数:15
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