A ratiometric fluorescence sensor based on molecular imprinting technology for rapid and visual detection of norfloxacin

被引:0
|
作者
Li, Chao [1 ,2 ]
Ma, Yangmin [1 ]
Fan, Cheng [2 ]
An, Yu [2 ]
Ma, Siyue [1 ]
机构
[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Key Lab Chem Addit China Natl Light Ind, Xian 710021, Shaanxi, Peoples R China
[2] Shaanxi Inst Prod Qual Supervis & Inspect, Xian 710048, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Ratiometric; Fluorescence sensor; Molecular imprinting; Visualization; Norfloxacin; FOOD; DOTS;
D O I
10.1016/j.saa.2024.125689
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
The problem of excessive use and abuse of antibiotics in the environment and food biology is becoming increasingly prominent, and norfloxacin (NOR) is widely used as an inexpensive and broad-spectrum antibiotic drug. Therefore, rapid and effective detection of antibiotics and residues in biological samples has become a demand of the times. This article describes a ratiometric fluorescence sensor based on molecular imprinting technology for the rapid and visual detection of NOR. A linear relationship (R-2 = 0.9977) was established between the ratio of self-fluorescence of NOR to the reference fluorescence from rhodamine B and NOR concentration (0-400 mu g/L), with a detection limit as low as 0.38 ng/mL, the detection time is as short as 8 min, and a high imprinting factor of 4.5. Visual detection of NOR was achieved through the change of fluorescence color from red to blue-purple. Satisfactory detection accuracy (RSD < 3.5 %) and recovery rate (90.03-102.10 %) were obtained through real sample spiking experiments and were highly consistent with HPLC-UV results. This ratiometric fluorescent sensor based on molecularly imprinting technology with high selectivity, sensitivity, rapidity, and visualization for detecting NOR in complex matrices has broad application prospects in the fields of rapid screening and on-site detection.
引用
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页数:8
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