Ferrocene Catalyzed Radical Cascade Cyclization of Aryl 1,6-Diynes: Access to Cyanoalkylsulfonyl Fluorenes

被引：0

作者：

Sriram, Ajmeera ^{[1
,2
]}

Ghouse, Abuthayir Mohamathu ^{[1
,2
]}

Akondi, Srirama Murthy ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol CSIR IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2025年

关键词：

Iron-catalysis; Radical cascade cyclization; Cyanoalkylsulfonylation; 1,6-diynes; IRON CATALYSIS;

D O I：

10.1002/asia.202401383

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A ferrocene-catalyzed cyanoalkylsulfonylative radical cascade cyclization of aryl 1,6-diynes using cycloketone oxime esters and DABCO.(SO2)(2) (DABSO) is reported. The reaction proceeds with notable chemo- and regioselectivity, without requiring additional oxidants or reductants. Interestingly, the methodology facilitates the formation of an unprecedented dicyanoalkylsulfonylated derivative in the case of electronically deficient aryl 1,6-diynes. Additionally, this transformation is compatible with substrates derived from drugs and bioactive molecules, highlighting its synthetic utility.

引用

页数：6

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