Immunosenescence and age-related immune cells: causes of age-related diseases

被引：0
|
作者：
Kim, Nam-Hee [1 ]
Sim, So-Jin [1 ]
Han, Hong-Gyu [1 ]
Yoon, Jeong-Hyuk [1 ]
Han, Yong-Hyun [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Coll Pharm, Lab Pathol & Physiol, Chuncheon Si 24341, Gangwon Do, South Korea
[2] Kangwon Natl Univ, Multidiment Genom Res Ctr, Chunchon 24341, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2025年 / 48卷 / 02期
关键词：
Immunosenescence; Age-related diseases; Aging; Immune cell; REGULATORY T-CELLS; REPLICATIVE SENESCENCE; CELLULAR SENESCENCE; B-CELLS; MACROPHAGES; EXPRESSION; LYMPHOCYTES; SUBSETS; MICE; EXPANSION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inflammation, causing tissue dysfunction and age-related diseases. Here, we discuss increased pro-inflammatory activity of aged macrophages, accumulation of lymphocytes with an age-associated phenotype, and specific alterations in both functions and characteristics of these immune cells. These cellular changes are associated with development of age-related diseases. Additionally, we reviewed various therapeutic strategies targeting age-related immunosenescence, providing pathways to mitigate effects of age-related diseases.
引用
收藏
页码：132 / 149
页数：18
相关论文
共 50 条
  • [41] Age-Related Diseases and Driving Safety
    Falkenstein, Michael
    Karthaus, Melanie
    Brune-Cohrs, Ute
    GERIATRICS, 2020, 5 (04) : 1 - 28
  • [42] The integration of inflammaging in age-related diseases
    Fulop, Tamas
    Witkowski, Jacek M.
    Olivieri, Fabiola
    Larbie, Anis
    SEMINARS IN IMMUNOLOGY, 2018, 40 (0C) : 17 - 35
  • [43] Phytochemicals and age-related eye diseases
    Rhone, Michael
    Basu, Arpita
    NUTRITION REVIEWS, 2008, 66 (08) : 465 - 472
  • [44] Telomere biology and age-related diseases
    Herrmann, Markus
    Pusceddu, Irene
    Marz, Winfried
    Herrmann, Wolfgang
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2018, 56 (08) : 1210 - 1222
  • [45] Body composition and age-related diseases
    Gillette-Guyonnet, S
    Vellas, B
    MECHANISMS OF AGEING AND DEVELOPMENT, 2003, 124 (03) : 247 - 248
  • [46] The role of mTOR in age-related diseases
    Chrienova, Zofia
    Nepovimova, Eugenie
    Kuca, Kamil
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1679 - 1693
  • [47] IPSCs, aging and age-related diseases
    Isobe, Ken-ichi (kisobe@med.nagoya-u.ac.jp), 1600, Elsevier B.V., Netherlands (31):
  • [48] An enzyme to cure age-related diseases
    Martinez, Paula
    Blasco, Maria A.
    NATURE CATALYSIS, 2021, 4 (09) : 738 - 739
  • [49] SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES
    Kellogg, Dean
    INNOVATION IN AGING, 2024, 8 : 453 - 453
  • [50] An enzyme to cure age-related diseases
    Paula Martinez
    Maria A. Blasco
    Nature Catalysis, 2021, 4 : 738 - 739
12345