Immunosenescence and age-related immune cells: causes of age-related diseases

被引：0
|
作者：
Kim, Nam-Hee [1 ]
Sim, So-Jin [1 ]
Han, Hong-Gyu [1 ]
Yoon, Jeong-Hyuk [1 ]
Han, Yong-Hyun [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Coll Pharm, Lab Pathol & Physiol, Chuncheon Si 24341, Gangwon Do, South Korea
[2] Kangwon Natl Univ, Multidiment Genom Res Ctr, Chunchon 24341, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2025年 / 48卷 / 02期
关键词：
Immunosenescence; Age-related diseases; Aging; Immune cell; REGULATORY T-CELLS; REPLICATIVE SENESCENCE; CELLULAR SENESCENCE; B-CELLS; MACROPHAGES; EXPRESSION; LYMPHOCYTES; SUBSETS; MICE; EXPANSION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inflammation, causing tissue dysfunction and age-related diseases. Here, we discuss increased pro-inflammatory activity of aged macrophages, accumulation of lymphocytes with an age-associated phenotype, and specific alterations in both functions and characteristics of these immune cells. These cellular changes are associated with development of age-related diseases. Additionally, we reviewed various therapeutic strategies targeting age-related immunosenescence, providing pathways to mitigate effects of age-related diseases.
引用
收藏
页码：132 / 149
页数：18
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