High-Pressure Reactor Technology for Aerated Biotransformations

被引：0

作者：

Niehaus, Daniel ^{[1
]}

Lyberis, Anastasios ^{[2
]}

Houssaini, Selma Iraqi ^{[1
]}

Perçin, Zeynep ^{[2
]}

Liebsch, Gregor ^{[3
]}

Bubenheim, Paul ^{[2
]}

Hoffmann, Marko ^{[1
]}

Liese, Andreas ^{[2
]}

Schlüter, Michael ^{[1
]}

机构：

[1] Institute of Multiphase Flows, Hamburg University of Technology, Eißendorfer Str. 38, Hamburg,21073, Germany

[2] Institute of Technical Biocatalysis, Hamburg University of Technology, Denickestr. 15, Hamburg,21073, Germany

[3] PreSens Precision Sensing GmbH, Am Biopark 11, Regensburg,93053, Germany

来源：

Chemical Engineering and Technology | 2025年 / 48卷 / 01期

关键词：

Glucose sensors - High pressure effects in solids - High pressure engineering - Optical variables measurement - Oxygen regulators - Process monitoring - Strain measurement - Velocity measurement;

D O I：

10.1002/ceat.202400043

中图分类号：

学科分类号：

摘要：

Utilizing pressure as a process parameter can make biotechnological processes more efficient and attractive compared to established ones. This paper presents a high-pressure reactor setup for enzymatically catalyzed gas–liquid reactions, which can be operated up to 15.0 MPa. The reactor is equipped with optical measurement technology for inline and in situ monitoring of the oxygen concentration under high-pressure conditions. The setup is characterized by assessing the influence of the process parameter pressure on the conversion of the glucose oxidation to d-glucono-δ-lactone by immobilized glucose oxidase. The study demonstrates that the increased oxygen availability due to higher solubility reduces the reaction time in a batch reactor from 270 to 90 min. © 2024 The Author(s). Chemical Engineering & Technology published by Wiley-VCH GmbH.

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