The impact of the physicochemical properties of calcium phosphate ceramics on biocompatibility and osteogenic differentiation of mesenchymal stem cells

被引：1
|
作者：
Skliarenko, Yuliia [1 ,2 ]
Kolomiiets, Volodymyr V. [3 ]
Balatskyi, Volodymyr V. [4 ]
Galuza, Yuliia [2 ,5 ]
Koryak, Oksana S. [6 ]
Macewicz, Larysa L. [2 ]
Ruban, Tetiana P. [2 ]
Firstov, Sergey A. [3 ]
Ulianchych, Nataliia. V. [3 ]
Piven, Oksana O. [2 ,4 ]
机构：
[1] Univ Clin Tubingen, Dept Internal Med Med Oncol & Pulmonol, AG Zender 8, Otfrie Muller Str 14, D-72076 Tubingen, Germany
[2] Natl Acad Sci Ukraine, Inst Mol Biol & Genet, Dept Human Genet, 150 Akad Zabolotnogo Str, UA-03680 Kiev, Ukraine
[3] Natl Acad Sci Ukraine, Frantsevich Inst Problems Mat Sci, Dept Phys Strength & Plast Mat, 3 Krzhizhanovcky Str, UA-03142 Kiev, Ukraine
[4] Polish Acad Sci, Nencki Inst Expt Biol, Lab Mol Med Biochem, 3 Pasteur Str, PL-02093 Warsaw, Poland
[5] Ctr Regenerat Therapies TU Dresden CRTD, Fetscherstr 105, D-01307 Dresden, Germany
[6] Frantsevich Inst Problems Mat Sci, Natl Acad Sci Ukraine, Dept phase transformat, 3 Krzhizhanovcky Str, UA-03142 Kiev, Ukraine
来源：
BMC RESEARCH NOTES | 2024年 / 17卷 / 01期
关键词：
Hydroxyapatite; Calcium phosphate ceramics; Stem cells; Biocompatibility; Osteogenesis; BETA-TRICALCIUM PHOSPHATE; IN-VITRO; BONE; CATENIN;
D O I：
10.1186/s13104-024-06937-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
ObjectiveIn this study we have focused on biocompatibility and osteoinductive capacity analysis of self-manufactured single-phase (HAP) and two-phase (HAP and beta-& Tcy;& Scy;& Rcy;) bioactive ceramics with various chemical modifications (Fig. 1).ResultsWe demonstrate a reduction in solubility for all analyzed composite after the treatment with H2O and H2O2, accompanied by an enhancement in adsorption activity. This modification also resulted in an increase in micro- and macroporosity, along with a rise in the open porosity. Adipose-derived mesenchymal stromal cells demonstrated excellent cell adhesion and survival when cultured with these ceramics. Calcium phosphate ceramics (H-500, HT-500, and HT-1 series) stimulated alkaline phosphatase expression, promoted calcium deposition, and enhanced osteopontin expression in ADSCs, independently inducing osteogenesis without additional osteogenic stimuli. These findings underscore the promising potential of HAP-based bioceramics for bone regeneration/reconstruction.
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页数：7
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