Visible-light-induced radical-cascade alkylation/cyclization of acrylamides: access to 3,3-dialkylated oxindoles

被引：0

作者：

Yang, Pengyuan ^{[1
]}

Wang, Lili ^{[1
]}

Yan, Meng ^{[1
]}

Yuan, Jinwei ^{[1
]}

Xiao, Yongmei ^{[1
]}

Yang, Liangru ^{[1
]}

Xu, Xiujuan ^{[2
]}

Qu, Lingbo ^{[3
,4
]}

机构：

[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Peoples R China

[2] CNTC, Key Lab Tobacco Flavor Basic Res CNTC, Zhengzhou Tobacco Res Inst, Zhengzhou 450001, Peoples R China

[3] Zhengzhou Univ, Sch Chem Engn, Zhengzhou 450001, Peoples R China

[4] Zhongyuan Inst Sci & Technol, Zhengzhou 451400, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 07期

关键词：

PHOTOREDOX CATALYSIS; H FUNCTIONALIZATION; N-ARYLACRYLAMIDES; ALKYLARYLATION; CYCLIZATION; ALKENES; OXYGEN;

D O I：

10.1039/d4ob01739k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light-induced deoxygenative alkylation/cyclization of acrylamides with alcohols activated by CS2 has been developed by using xanthate salts as alkyl radical precursors in the presence of tricyclohexylphosphine. It proceeds through a tandem radical addition/cyclization process, and this protocol provides a reliable and practical approach to building the skeleton of 3,3-disubstituted oxindoles in moderate to good yields. Notable features of this reaction include readily available starting reagents, broad substrate scope and mild reaction conditions.

引用

页码：1653 / 1661

页数：9

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