Molecular gene signature of circulating stromal/stem cells

被引：0
|
作者：
Lin, Weiping [1 ,2 ]
Xu, Liangliang [3 ]
Li, Gang [4 ,5 ]
Tortorella, Micky Daniel [1 ,6 ]
机构：
[1] Chinese Acad Sci, Hong Kong Inst Sci & Innovat, Ctr Regenerat Med & Hlth, Hong Kong, Peoples R China
[2] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England
[3] Guangzhou Univ Chinese Med, Key Lab Orthopaed & Traumatol, Affiliated Hosp 1, Lingnan Med Res Ctr, Guangzhou, Guangdong, Peoples R China
[4] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci,Shenzhen Res Inst,Fac Me, Lui Che Woo Inst Innovat Med,Dept Orthopaed &Traum, Hong Kong, Peoples R China
[5] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Shenzhen, Peoples R China
[6] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou, Peoples R China
来源：
JOURNAL OF HUMAN GENETICS | 2025年
基金：
中国国家自然科学基金;
关键词：
MESENCHYMAL STEM-CELLS; COUPLED RECEPTOR GPR4; BONE-MARROW; GROWTH/DIFFERENTIATION FACTOR-5; PERIPHERAL-BLOOD; GROWTH-FACTOR; DIFFERENTIATION; EXPRESSION; PH; CHONDROGENESIS;
D O I：
10.1038/s10038-025-01322-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The human skeleton is renewed and regenerated throughout life, by a cellular process known as bone remodeling. Stem cells are clono-genic cells that are capable of differentiation into multiple mature cell types (multipotency), and simultaneously replenishing stem cell pool (self-renewal), which allows them to sustain tissue development and maintenance. Circulating mesenchymal stromal/stem cells (MSCs), are mobile adult stem cells with specific gene expression profiling, as well as enhanced mitochondrial remodeling as a promising source for personalized cell and gene therapy. A global LGR5-associated genetic interaction network highlights the functional organization and molecular phenotype of circulating MSCs.
引用
收藏
页码：275 / 280
页数：6
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