Fast, Simple, and Sensitive Voltammetric Measurements of Acyclovir in Real Samples via Boron-Doped Diamond Electrode

The voltammetric acyclovir (ACV) trace-level determination procedure has been introduced. This is the first time that a commercially available boron-doped diamond electrode (BDDE) coupled with differential-pulse voltammetry (DPV) has been used for this purpose. The commercially available BDDE is characterized by a short response time, low background current, and very good analytical parameters of ACV determination. Ultimately, DPV measurements using the BDDE in 0.075 mol L−1 PBS with a pH of 7.2 under optimized conditions achieved the lowest detection limit (LOD = 0.0299 nmol L−1) reported in the literature for voltammetric procedures. Moreover, it is highly resistant to the presence of various interfering agents and has been used to analyze pharmaceutical and municipal wastewater samples. The obtained results are consistent with measurements made using chromatographic reference methods. © 2024 by the authors.