Clinically probable RBD is an early predictor of malignant non-motor Parkinson's disease phenotypes

被引：0
|
作者：
Martinez-Nunez, Alfonso Enrique [1 ]
Hutchinson, Hunter [2 ]
Coutinho, Patricia [1 ]
Sarmento, Filipe Pereira [1 ]
Lavu, Venkat Srikar [1 ]
Yuan, Qingqi [3 ]
Dwarampudi, Jagan Mohan Reddy [3 ]
Gunduz, Aysegul [1 ,4 ]
Pontone, Gregory M. [1 ]
Okun, Michael S. [1 ]
Wong, Joshua K. [1 ]
机构：
[1] Univ Florida, Norman Fixel Inst Neurol Dis, Gainesville, FL 32611 USA
[2] Univ Florida, Coll Med, Gainesville, FL USA
[3] Univ Florida, Coll Liberal Arts & Sci, Gainesville, FL USA
[4] Univ Florida, Crayton Pruitt Family Dept Biomed Engn J, Gainesville, FL USA
来源：
NPJ PARKINSONS DISEASE | 2025年 / 11卷 / 01期
关键词：
NUCLEUS-ACCUMBENS; DEMENTIA; PROGRESSION; SYMPTOMS; QUESTIONNAIRE; DISORDERS; DIAGNOSIS; PATHOLOGY; APATHY; SCALE;
D O I：
10.1038/s41531-025-00874-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Non-motor symptoms (NMS) in Parkinson's disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and cognitive decline. This study explores how early RBD can predict the development of NMS profiles in patients, comparing those with and without early RBD. We identified a unique NMS profile associated with early RBD. These patients had a higher rate of cognitive impairment (M-2 = 326.84, p < 0.001), apathy (M-2 = 332.93, p < 0.001), hallucinations (M-2 = 480.05, p < 0.001), depression (M-2 = 480.05, p < 0.0001), anxiety (corrected p < 0.01), impulse control disorders (M-2 = 77.577, p < 0.001), and autonomic dysfunction (F = 251.8, p < 0001). A survival analysis revealed an association between early RBD and faster progression to cognitive impairment. These NMS profiles may play a critical role in stratifying patients for targeted interventions.
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页数：7
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