Associations of cachexia and frailty with amyotrophic lateral sclerosis

被引：0

作者：

Peters, Tracy L. ^{[1
,2
]}

Qiu, Weihong ^{[2
,3
]}

Yang, Haomin ^{[2
,4
]}

Huang, Wuqing ^{[2
]}

Hu, Yizhen ^{[2
,5
]}

Zou, Zhangyu ^{[1
]}

Ye, Weimin ^{[2
,3
,4
]}

机构：

[1] Fujian Med Univ, Dept Neurol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China

[2] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Fuzhou 350122, Fujian, Peoples R China

[3] Fujian Med Univ, Inst Populat Med, Sch Publ Hlth, Fuzhou 350122, Fujian, Peoples R China

[4] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

[5] Fujian Med Univ, Fujian Prov Key Lab Environm Factors & Canc, Fuzhou 350000, Fujian, Peoples R China

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Amyotrophic lateral sclerosis; Epidemiology; Frailty; Cachexia; POPULATION; SYSTEM; RISK;

D O I：

10.1038/s41598-025-89080-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.

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页数：9

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