Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis

被引：0

作者：

Balashov, A. V. ^{[1
]}

Balashov, V. P. ^{[1
]}

Shikhanov, N. P. ^{[2
]}

Gushchina, S. V. ^{[1
]}

机构：

[1] NP Ogarev Natl Res Mordovia State Univ, Dept Cytol Histol Embryol, Courses Med Biol & Mol Biol Cell, Saransk, Republic Of Mor, Russia

[2] NP Ogarev Natl Res Mordovia State Univ, Dept Normal & Pathol Anat, Course Forens Med, Saransk, Republic Of Mor, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年

关键词：

CSF-1; motor neurons; experimental autoimmune encephalomyelitis; spinal cord;

D O I：

10.1007/s10517-024-06249-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.

引用

页码：682 / 685

页数：4

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