Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis

被引：0
|
作者：
Balashov, A. V. [1 ]
Balashov, V. P. [1 ]
Shikhanov, N. P. [2 ]
Gushchina, S. V. [1 ]
机构：
[1] NP Ogarev Natl Res Mordovia State Univ, Dept Cytol Histol Embryol, Courses Med Biol & Mol Biol Cell, Saransk, Republic Of Mor, Russia
[2] NP Ogarev Natl Res Mordovia State Univ, Dept Normal & Pathol Anat, Course Forens Med, Saransk, Republic Of Mor, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年
关键词：
CSF-1; motor neurons; experimental autoimmune encephalomyelitis; spinal cord;
D O I：
10.1007/s10517-024-06249-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.
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页码：682 / 685
页数：4
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