Genoprotective Properties of para-Tyrosol against Doxorubicin-Induced DNA Damage in Sperm and Testicular Tissue Cells of Rats

被引：0
|
作者：
Borovskaya, T. G. [1 ]
Vychuzhanina, A. V. [1 ]
Schemerova, Yu. A. [1 ]
Stremlina, L. A. [1 ]
Goldberg, V. E. [2 ]
Dygai, A. M. [1 ]
Zhdanov, V. V. [1 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Tomsk Natl Med Res Ctr, Res Inst Oncol, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2025年 / 178卷 / 04期
关键词：
DNA comets; testicular tissue; sperm; doxorubicin; para-tyrosol;
D O I：
10.1007/s10517-025-06374-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of para-tyrosol (PT), a hydroxyalkylphenol exhibiting antioxidant properties, on the level of DNA damage in testicular tissue cells and sperm of rats treated with doxorubicin was studied using the DNA comet assay. N-acetylcysteine (NAC) was used as a reference drug. It was found that both drugs reduced the number of DNA breaks in rat testicular tissue cells (by 46-48%). The antigenotoxic effect, judging by %DNA in tail, in relation to spermatozoa was detected only in PT. The number of DNA damage in male germ cells after treatment with PT was reduced by 52% from the control (administration of doxorubicin alone). The results suggest that it is advisable to use PT in order to reduce the genotoxicity of doxorubicin, in the therapy of Hodgkin lymphoma (HL) in treatment regimens containing this anthracycline antibiotic.
引用
收藏
页码：567 / 570
页数：4
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