Palladium catalyzed ortho-C(sp2)-H activation/cyclization of aryl amines assisted by imine and vinylacetic acid

Palladium-catalyzed directed C - H functionalization/cyclization is an effective approach for synthesizing nitrogen heterocycles. Imine, known for its ease of installation/removal, has been extensively used in the C-H activation of aldehydes, ketones, and alkylamines. Nevertheless, it has been rarely explored in the C(sp2)-H activation of aryl amines because of the generation of a strained four-membered palladacycle. Herein, an imine directed palladium catalyzed C(sp2)-H functionalization of aryl amines assisted by vinylacetic acid is established, providing access to a variety of gamma-lactone fused tetrahydroquinolines under mild reaction conditions. The methodology demonstrates broad substrate scope and good functional group tolerance, representing notable advancement in organic synthesis. Mechanistic experiments are performed to clarify how the C(sp2)-H activation occurs, indicating the crucial role of vinylacetic acid. DFT calculations supports the observations, elucidating the strained four-membered ring C-H activation barrier is overcome via coordination and hydrogen bond interaction of vinylacetic acid. Imines are often used as directing/chelating groups in C(sp3)-H activations of due to their ease of installation and removal, but have been rarely explored in the context of aryl C(sp2)-H activations of aryl amines given the strained intermediate that would follow. Here, the authors report a methodology for C(sp2)-H functionalization of aryl amines via palladium catalysis, assisted by vinylacetic acid, which putatively reduces the necessity of a four-membered strained intermediate.