Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

被引：0

作者：

Takano, Yuma ^{[1
,2
]}

Suzuki, Jun ^{[3
,4
]}

Nomura, Kotaro ^{[3
]}

Fujii, Gento ^{[1
]}

Zenkoh, Junko ^{[1
]}

Kawai, Hitomi ^{[5
]}

Kuze, Yuta ^{[1
]}

Kashima, Yukie ^{[1
]}

Nagasawa, Satoi ^{[1
]}

Nakamura, Yuka ^{[6
]}

Kojima, Motohiro ^{[6
]}

Tsuchihara, Katsuya ^{[7
]}

Seki, Masahide ^{[1
]}

Kanai, Akinori ^{[1
]}

Matsubara, Daisuke ^{[5
]}

Kohno, Takashi ^{[8
]}

Noguchi, Masayuki ^{[5
,9
]}

Nakaya, Akihiro ^{[1
]}

Tsuboi, Masahiro ^{[3
]}

Ishii, Genichiro ^{[6
]}

Suzuki, Yutaka ^{[1
]}

Suzuki, Ayako ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Kashiwa, Chiba, Japan

[2] Chugai Pharmaceut Co Ltd, Pharmaceut Sci Dept, Chuo Ku, Tokyo, Japan

[3] Natl Canc Ctr Hosp East, Dept Thorac Surg, Kashiwa, Chiba, Japan

[4] Juntendo Univ, Grad Sch Med, Dept Gen Thorac Surg, Tokyo, Tokyo, Japan

[5] Univ Tsukuba, Fac Med, Dept Diagnost Pathol, Tsukuba, Ibaraki, Japan

[6] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Pathol, Kashiwa, Chiba, Japan

[7] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Translat Informat, Kashiwa, Chiba, Japan

[8] Natl Canc Ctr Res Inst, Div Genome Biol, Chuo Ku, Tokyo, Japan

[9] Shonan Kamakura Gen Hosp, Ctr Clin & Translat Sci, Kamakura, Kanagawa, Japan

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

日本学术振兴会;

关键词：

MATRIX METALLOPROTEINASES; INTEGRATED ANALYSIS; CELL; METASTASIS; REGULATORS; MECHANISMS; CXCL14;

D O I：

10.1038/s41467-024-54671-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interaction of tumor cells and their microenvironment is thought to be a key factor in tumor development. We present spatial RNA profiles obtained from 30 lung adenocarcinoma patients at the non-invasive and later invasive stages. We use spatial transcriptome sequencing data in conjunction with in situ RNA profiling to conduct higher resolution analyses. The detailed examination of each case, as well as the subsequent computational analyses based on the observed diverse profiles, reveals that significant changes in the phenotypic appearances of tumor cells are frequently associated with changes in immune cell features. The phenomenon coincides with the induction of a series of cellular expression programs that enable tumor cells to transform and break through the immune cell barrier, allowing them to progress further. The study shows how lung tumors develop through interaction in their microenvironments.

引用

页数：17

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