Practical control of poultry diseases in Africa remains a considerable challenge, impacting food security, livelihoods, and public health. National Poultry Improvement Plan (NPIP) is a combined industry, state, and federal initiative to address specific poultry diseases. Implementing an NPIP offers Africa a promising disease management and prevention avenue. This article aims to evaluate the implementation status of the NPIP in diverse African countries, analyze the challenges faced in adopting and executing NPIP strategies within the continent’s poultry industry, and the prospects for enhancing poultry disease control efforts. This review provides more detailed information about the importance of NPIP in fortifying Africa’s poultry industry against diseases, ensuring food security, and driving economic growth. Collaboration among stakeholders, policymakers, and researchers is paramount to realize the full potential of the NPIP and pave the way for a healthier and more resilient poultry sector in Africa.