Risk factors for wet macular degeneration: a systematic review, with novel insights from the Scottish Heart Health Extended Cohort

被引:1
|
作者
Fitton, Catherine A. [1 ]
Quigley, Madeleine M. R. [1 ]
Belch, Jill J. F. [1 ]
机构
[1] Univ Dundee, Ninewells Hosp, Div Mol & Clin Med, Mailbox 1, Dundee DD1 9SY, Scotland
关键词
Macular degeneration; Risk factors; Cigarette smoking; ALCOHOL-CONSUMPTION; AGE; SMOKING;
D O I
10.1186/s12886-025-03868-5
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
BackgroundAge-related macular degeneration (AMD) is a major cause of vision loss worldwide. This study aimed to assess risk factors for wet AMD by two methods: assessing risk factors measured in the Scottish Heart Health Extended Cohort (SHHEC), and to systematically review the literature.MethodsEighteen thousand one hundred seven volunteers were recruited to SHHEC between 1984-1995, with risk factor data collected on recruitment. Hospital records were linked to study data up to 2017 and survival analysis was used to analyse risk factors and wet AMD. Literature published between 2000-2023 was searched for studies assessing risk factors for wet AMD, resulting in 5,503 papers. Following review, 7 studies were included in the systematic review.ResultsWithin the SHHEC data, 231 cases of wet AMD were reported. Increasing age (Hazard Ratio (HR) 10.51; 99% Confidence Interval (CI) 4.78-23.11) and smoking (HR 1.67; 99% CI 1.17-2.38) were significantly associated with an increased risk of wet AMD. Increased dietary intake of vitamin K (HR 0.56; 99% CI 0.34-0.94) was associated with a decreased risk of wet AMD.According to a systematic review, smoking, high Body mass index, heavy alcohol intake, increased systolic blood pressure, increased pulse pressure, and high levels of C-reactive protein and serum triglycerides in the blood may be associated with an increased risk of wet AMD. However, the studies provide mixed evidence and no conclusive results.ResultsWithin the SHHEC data, 231 cases of wet AMD were reported. Increasing age (Hazard Ratio (HR) 10.51; 99% Confidence Interval (CI) 4.78-23.11) and smoking (HR 1.67; 99% CI 1.17-2.38) were significantly associated with an increased risk of wet AMD. Increased dietary intake of vitamin K (HR 0.56; 99% CI 0.34-0.94) was associated with a decreased risk of wet AMD.According to a systematic review, smoking, high Body mass index, heavy alcohol intake, increased systolic blood pressure, increased pulse pressure, and high levels of C-reactive protein and serum triglycerides in the blood may be associated with an increased risk of wet AMD. However, the studies provide mixed evidence and no conclusive results.ConclusionWe have demonstrated that increasing age and smoking are high-risk factors for the development of wet AMD, while vitamin K is associated with a reduced risk of wet AMD.
引用
收藏
页数:14
相关论文
共 48 条
  • [11] Does fibrinogen add to prediction of cardiovascular disease? Results from the Scottish Heart Health Extended Cohort Study
    Woodward, Mark
    Tunstall-Pedoe, Hugh
    Rumley, Ann
    Lowe, Gordon D. O.
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 146 (04) : 442 - 446
  • [12] The Incremental Value of Fibrinogen in the Prediction of Cardiovascular Disease: Results from the Scottish Heart Health Extended Cohort Study
    Lowe, Gordon D.
    Woodward, Mark
    Tunstall-Pedoe, Hugh
    Rumley, Ann
    CIRCULATION, 2009, 119 (10) : E312 - E312
  • [13] Challenges in Age-Related Macular Degeneration: From Risk Factors to Novel Diagnostics and Prevention Strategies
    Lombardo, Marco
    Serrao, Sebastiano
    Lombardo, Giuseppe
    FRONTIERS IN MEDICINE, 2022, 9
  • [14] Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish Heart Health Extended Cohort Study
    Juraschek, Stephen P.
    Tunstall-Pedoe, Hugh
    Woodward, Mark
    ATHEROSCLEROSIS, 2014, 233 (02) : 623 - 629
  • [15] Epidemiology of heart failure: incidence, prevalence, and risk factors from a systematic review
    Lam, C.
    Stokes, M.
    Qin, L.
    Medina, J.
    Nambiar, S.
    Saraiva, G.
    EUROPEAN JOURNAL OF HEART FAILURE, 2019, 21 : 62 - 62
  • [16] VARIATION IN CORONARY RISK-FACTORS BY SOCIAL-STATUS - RESULTS FROM THE SCOTTISH HEART HEALTH STUDY
    SHEWRY, MC
    SMITH, WCS
    WOODWARD, M
    TUNSTALLPEDOE, H
    BRITISH JOURNAL OF GENERAL PRACTICE, 1992, 42 (363): : 406 - 410
  • [17] Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis
    Zhang, Yifei
    Zhang, Zeyu
    Cao, Zijing
    Bai, Xuehui
    Zhang, Shujiao
    Zhang, Shuaixing
    Tang, Jingyi
    Xi, Junyu
    Xie, Yiran
    Wu, Yuqi
    Liu, Zhongjie
    Liu, Weijing
    BMC MUSCULOSKELETAL DISORDERS, 2025, 26 (01)
  • [18] Progression from Early/Intermediate to Advanced Forms of Age-Related Macular Degeneration in a Large UK Cohort: Rates and Risk Factors
    Chakravarthy, Usha
    Bailey, Clare C.
    Scanlon, Peter H.
    McKibbin, Martin
    Khan, Rehna S.
    Mahmood, Sajjad
    Downey, Louise
    Dhingra, Narendra
    Brand, Christopher
    Brittain, Christopher J.
    Willis, Jeffrey R.
    Venerus, Alessandra
    Muthutantri, Anushini
    Cantrell, Ronald A.
    OPHTHALMOLOGY RETINA, 2020, 4 (07): : 662 - 672
  • [19] Vascular Risk Factors and Brain Health in Aging: Insights from a Community-Based Cohort Study
    Wang, Wenxiao
    Yang, Yiru
    Sang, Feng
    Chen, Yaojing
    Li, Xin
    Chen, Kewei
    Wang, Jun
    Zhang, Zhanjun
    JOURNAL OF ALZHEIMERS DISEASE, 2024, 99 (04) : 1361 - 1374
  • [20] Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review
    Lin, Shanshan
    Yang, Zhihua
    Liu, Yangxi
    Bi, Yingfei
    Liu, Yu
    Zhang, Zeyu
    Zhang, Xuan
    Jia, Zhuangzhuang
    Wang, Xianliang
    Mao, Jingyuan
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (25) : 1992 - 2008